Infantile status epilepticus disrupts myelin development.
Infantile status epilepticus disrupts myelin development.
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DOI：
10.1016/j.nbd.2021.105566
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发表时间：
2022-01
影响因子：
6.1
通讯作者：
Gröhn O
中科院分区：
文献类型：
--
作者：
Bencurova P;Laakso H;Salo RA;Paasonen E;Manninen E;Paasonen J;Michaeli S;Mangia S;Bares M;Brazdil M;Kubova H;Gröhn O
颞叶癫痫(TLE)是成人中最常见的癫痫类型，通常始于婴儿期或儿童早期。尽管TLE最初被认为是一种灰质病理，但越来越多的证据表明这种疾病与白质异常有关。在本研究中，我们利用Li-匹罗卡品诱导的出生后第12天(P)的TLE大鼠模型，探讨了TLE在未成熟脑内的发生和发展对脑白质完整性和发育的影响。弥散张量成像(DTI)和黑金II组织学检查发现，在P28时，主要白质轨迹(胼胝体、内囊和外囊，以及大脑深层白质)均有破坏。在TLE诱导后三个月，这些异常大多不再存在，只有在外囊和大脑深层白质中可以检测到有限的异常。在第4级旋转框架中沿虚拟区域的松弛显示，在P28和P72这两个时间点观察到的白质变化与髓鞘含量的降低是一致的。受TLE诱导的白质异常影响的动物在成年后表现出丘脑与内侧前额叶和躯体感觉皮质之间的功能连接增加。此外，对P15和P18的其他动物组的组织学分析显示，白质完整性只有轻微的变化，这表明TLE进展的影响是逐渐与年龄相关的。总而言之，未成熟大脑中的TLE进展扭曲了脑白质的发育，在出生后第28天左右达到顶峰，随后在成年后大幅恢复。这种发育迟缓可能导致认知和行为并存，这是早发性TLE的典型症状。
Temporal lobe epilepsy (TLE) is the most prevalent type of epilepsy in adults; it often starts in infancy or early childhood. Although TLE is primarily considered to be a grey matter pathology, a growing body of evidence links this disease with white matter abnormalities. In this study, we explore the impact of TLE onset and progression in the immature brain on white matter integrity and development utilising the rat model of Li-pilocarpine-induced TLE at the 12th postnatal day (P). Diffusion tensor imaging (DTI) and Black-Gold II histology uncovered disruptions in major white matter tracks (corpus callosum, internal and external capsules, and deep cerebral white matter) spreading through the whole brain at P28. These abnormalities were mostly not present any longer at three months after TLE induction, with only limited abnormalities detectable in the external capsule and deep cerebral white matter. Relaxation Along a Fictitious Field in the rotating frame of rank 4 indicated that white matter changes observed at both timepoints, P28 and P72, are consistent with decreased myelin content. The animals affected by TLE-induced white matter abnormalities exhibited increased functional connectivity between the thalamus and medial prefrontal and somatosensory cortex in adulthood. Furthermore, histological analyses of additional animal groups at P15 and P18 showed only mild changes in white matter integrity, suggesting a gradual age-dependent impact of TLE progression. Taken together, TLE progression in the immature brain distorts white matter development with a peak around postnatal day 28, followed by substantial recovery in adulthood. This developmental delay might give rise to cognitive and behavioural comorbidities typical for early-onset TLE.
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影响因子：
3
作者：
Bock, Nicholas A.;Kocharyan, Ara;Liu, Junjie V.;Silva, Afonso C.
通讯作者：
Silva, Afonso C.
影响因子：
4.8
作者：
Doucet, Gaelle;Osipowicz, Karol;Sharan, Ashwini;Sperling, Michael R.;Tracy, Joseph I.
通讯作者：
Tracy, Joseph I.
影响因子：
2.2
作者：
Govindan, Rajkumar Munian;Makki, Malek I.;Chugani, Harry T.
通讯作者：
Chugani, Harry T.
影响因子：
5.6
作者：
Hermann, B;Seidenberg, M;Magnotta, V
通讯作者：
Magnotta, V
DOI：
10.1006/jmrb.1994.1037
发表时间：
1994-03-01
期刊：
JOURNAL OF MAGNETIC RESONANCE SERIES B
影响因子：
--
作者：
BASSER, PJ;MATTIELLO, J;LEBIHAN, D
通讯作者：
LEBIHAN, D