Retinal thickness analysis by race, gender, and age using Stratus OCT.
Retinal thickness analysis by race, gender, and age using Stratus OCT.
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DOI：
10.1016/j.ajo.2009.09.025
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发表时间：
2010-03
影响因子：
4.2
通讯作者：
Nguyen, Quan Dong
中科院分区：
文献类型：
--
作者：
Kashani, Amir H.;Zimmer-Galler, Ingrid E.;Shah, Syed Mahmood;Dustin, Laurie;Do, Diana V.;Eliott, Dean;Haller, Julia A.;Nguyen, Quan Dong
使用Stratus OCT™检测不同种族、性别和年龄患者的视网膜厚度差异。横断面研究。在一项多中心、以大学为基础的研究中，纳入了126名无眼部疾病史的患者（78名无视网膜病变的糖尿病患者和48名非糖尿病患者）。使用Stratus OCT™进行光学相干断层扫描测量。中心凹厚度和平均中心凹厚度的统计学比较使用广义估计方程调整糖尿病状态，种族，年龄和性别。研究人群包括36%的男性，39%的白人，33%的非洲裔美国人和28%的西班牙裔。糖尿病患者和非糖尿病患者的平均中心凹厚度分别为191.6±2.7µm和194.5±2.7µm（P=0.49）。男性的平均中心凹厚度显著大于女性（分别为201.8±2.7µm和186.9±2.6µm; P<0.001）。高加索人的平均中央凹厚度为200.2±2.7µm，非裔美国人为181.0±3.7µm，西班牙裔美国人为194.7±3.9µm。非裔美国人的平均中央凹厚度显著低于白人（P <0.0001）或西班牙裔（P=0.005）。中心凹厚度和中心凹平均厚度随年龄增长而增加。不同种族、性别和年龄的受试者之间的视网膜厚度存在统计学显著差异。与白人和西班牙裔相比，非洲裔美国人是平均中心凹厚度降低的预测因子;男性（不考虑种族）是平均中心凹厚度增加的重要预测因子。当控制年龄、种族和性别的数据时，糖尿病患者和非糖尿病患者的平均中心凹厚度相似。这些结果表明，比较OCT测量的研究应仔细控制视网膜厚度的年龄，种族和性别差异。
To detect differences in retinal thickness among patients of different race, gender and age using Stratus OCT™. Cross-sectional study. In a multicenter, university-based study, 126 patients with no history of ocular disease were enrolled (78 diabetics without retinopathy and 48 nondiabetics). Optical coherence tomography measurements were performed using Stratus OCT™. Statistical comparisons of centerpoint foveal thickness and mean foveal thickness were made using generalized estimating equations adjusting for diabetic status, race, age, and gender. The study population consisted of 36% males, 39% Caucasians, 33% African Americans, and 28% Hispanics. Mean foveal thickness was 191.6±2.7µm and 194.5±2.7µm for diabetics and nondiabetics, respectively (P=0.49). Mean foveal thickness in males was significantly larger than in females (201.8±2.7µm and 186.9±2.6µm, respectively; P<0.001). Mean foveal thickness was 200.2±2.7µm for Caucasians, 181.0±3.7µm for African Americans, and 194.7±3.9µm for Hispanics. Mean foveal thickness was significantly less for African Americans than Caucasians (P <0.0001) or Hispanics (P=0.005). Centerpoint foveal thickness and mean foveal thickness showed a significant increase with age. There are statistically significant differences in retinal thickness between subjects of different race, gender, and age. When compared to Caucasians and Hispanics, African-American race is a predictor of decreased mean foveal thickness; and male sex (regardless of race) is a significant predictor of increased mean foveal thickness. Mean foveal thickness is similar among diabetics and nondiabetics when data are controlled for age, race, and sex. These results suggest that studies comparing OCT measurements should carefully control for age, race, and gender-based variations in retinal thickness.
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影响因子：
2.4
作者：
Manassakorn, Anita;Chaidaroon, Winai;Wattananikorn, Sopa
通讯作者：
Wattananikorn, Sopa
影响因子：
2.6
作者：
Sugimoto, M;Sasoh, M;Uji, Y
通讯作者：
Uji, Y
影响因子：
1.7
作者：
Massin, P;Erginay, A;Gaudric, A
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Gaudric, A
DOI：
10.1016/s0008-4182(04)80054-1
发表时间：
2004-02-01
影响因子：
4.2
作者：
Cavallotti, C;Artico, M;Feher, J
通讯作者：
Feher, J
影响因子：
4.4
作者：
Paunescu, LA;Schuman, JS;Fujimoto, JG
通讯作者：
Fujimoto, JG