Yeast Probiotics Shape the Gut Microbiome and Improve the Health of Early-Weaned Piglets.
Yeast Probiotics Shape the Gut Microbiome and Improve the Health of Early-Weaned Piglets.
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DOI：
10.3389/fmicb.2018.02011
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发表时间：
2018
影响因子：
5.2
通讯作者：
Pu W
中科院分区：
文献类型：
--
作者：
Xu J;Li Y;Yang Z;Li C;Liang H;Wu Z;Pu W
断奶是猪生活中最具压力的挑战之一，它导致肠道和免疫系统功能障碍，破坏肠道微生物生态系统，从而损害仔猪的生长性能和健康。为了减轻应激对早期断奶仔猪的负面影响，需要采取有效措施促进肠道健康。为此，我们驯化了一株酿酒酵母菌，并开发了益生菌短奶安，这是一种驯化的酿酒酵母菌培养物。酿酒酵母对鸡蛋白色。本研究旨在探讨短奶安对早期断奶仔猪生长和健康的影响，并分析其对粪便微生物群的影响。结果表明，短奶安能显著提高早期断奶仔猪的增重和采食量，降低腹泻和死亡率。肠道菌群的分析表明，细菌群落由Duan-Nai-An形成，并保持为相对稳定的结构，表现为在断奶早期具有较高的核心OTU数和较低的未加权UniFrac距离。然而，真菌群落没有显着的酵母益生菌塑造。值得注意的是，13个细菌属被发现与Duan-Nai-An喂养，包括肠球菌属，琥珀弧菌属，瘤胃球菌属，Sharpea，脱硫弧菌属，RFN 20，Sphaerochaeta，消化球菌属，厌氧菌属，和其他4个未定义的属。这些结果表明短奶安具有作为猪生产中的饲料添加剂的潜力。
Weaning is one of the most stressful challenges in the pig’s life, which contributes to dysfunctions of intestinal and immune system, disrupts the gut microbial ecosystem, and therefore compromises the growth performance and health of piglets. To mitigate the negative impact of the stress on early-weaned piglets, effective measures are needed to promote gut health. Toward this end, we tamed a Saccharomyces cerevisiae strain and developed a probiotic Duan-Nai-An, which is a yeast culture of the tamed S. cerevisiae on egg white. In this study, we tested the performance of Duan-Nai-An on growth and health of early-weaned piglets and analyzed its impact on fecal microbiota. The results showed that Duan-Nai-An significantly improved weight gain and feed intake, and reduced diarrhea and death of early-weaned piglets. Analysis of the gut microbiota showed that the bacterial community was shaped by Duan-Nai-An and maintained as a relatively stable structure, represented by a higher core OTU number and lower unweighted UniFrac distances across the early weaned period. However, fungal community was not significantly shaped by the yeast probiotics. Notably, 13 bacterial genera were found to be associated with Duan-Nai-An feeding, including Enterococcus, Succinivibrio, Ruminococcus, Sharpea, Desulfovibrio, RFN20, Sphaerochaeta, Peptococcus, Anaeroplasma, and four other undefined genera. These findings suggest that Duan-Nai-An has the potential to be used as a feed supplement in swine production.
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影响因子：
4.5
作者：
Broadway PR;Carroll JA;Sanchez NC
通讯作者：
Sanchez NC
DOI：
10.1126/science.1224203
发表时间：
2012-06-08
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Costello EK;Stagaman K;Dethlefsen L;Bohannan BJ;Relman DA
通讯作者：
Relman DA
影响因子：
30.3
作者：
Backhed, Fredrik;Roswall, Josefine;Jun, Wang
通讯作者：
Jun, Wang
影响因子：
--
作者：
Graf D;Di Cagno R;Fåk F;Flint HJ;Nyman M;Saarela M;Watzl B
通讯作者：
Watzl B
影响因子：
14.9
作者：
Cole JR;Wang Q;Cardenas E;Fish J;Chai B;Farris RJ;Kulam-Syed-Mohideen AS;McGarrell DM;Marsh T;Garrity GM;Tiedje JM
通讯作者：
Tiedje JM