Do sex hormones or hormone therapy modify the relation of n-3 fatty acids with incident depressive symptoms in postmenopausal women? The MESA Study.
Do sex hormones or hormone therapy modify the relation of n-3 fatty acids with incident depressive symptoms in postmenopausal women? The MESA Study.
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DOI：
10.1016/j.psyneuen.2016.10.003
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发表时间：
2017-01
影响因子：
3.7
通讯作者：
Liu K
中科院分区：
文献类型：
--
作者：
Colangelo LA;Ouyang P;Golden SH;Szklo M;Gapstur SM;Vaidya D;Liu K
考虑到雌二醇（E2）和n-3多不饱和脂肪酸（PUFAs）在神经发生和神经传递中的作用，我们研究了PUFAs与绝经后妇女抑郁症状的相关性是否受激素治疗（HT）或雌激素状态的影响。在多种族动脉粥样硬化研究中，基线（2000-02）无抑郁症状的女性（N=1616）根据HT使用和饮食二十碳五烯酸（EPA）、二十二碳六烯酸（DHA）和EPA+DHA总和的四分位数进行分类。血清E2 ≤0.073 nmol/L（样本中位数）的女性被归类为E2低。采用Poisson回归对第3次检查（2004-05）时的偶发抑郁症状进行建模，根据流行病学研究中心抑郁量表≥16或服用抗抑郁药进行定义，首先作为HT使用和n-3 PUFA四分位数的函数，其次作为低E2状态和n-3 PUFA四分位数的函数。在HT非使用者中，PUFAs与抑郁症状之间存在正相关性（p趋势≤0.003）。与最低四分位数相比，EPA、DHA和EPA+DHA的最高四分位数的校正风险比（RR）分别为2.10、2.39和2.04。对于HT用户，没有看到任何关联。当对E2状态进行分析时，PUFA四分位数的RR为阳性，并对低E2女性进行分级，但对高E2女性为零。与假设相反，较高的DHA和EPA摄入量与非HT使用者的抑郁症状风险较高相关。
Considering that estradiol (E2) and n-3 polyunsaturated fatty acids (PUFAs) have roles in neurogenesis and in neurotransmission, we examined whether the association of PUFAs with incident depressive symptoms in postmenopausal women is modified by hormone therapy (HT) use or estrogen status. Women (N=1616) free of depressive symptoms at baseline (2000-02) in the Multi-Ethnic Study of Atherosclerosis were classified by HT usage and quartiles of dietary eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA), and the sum EPA+DHA. Women with serum E2 ≤0.073 nmol/L (sample median), were classified low on E2. Poisson regression was used to model incident depressive symptoms at examination 3 (2004-05), defined by the Center for Epidemiological Studies Depression Scale ≥16 or taking an antidepressant, first as a function of HT use and n-3 PUFA quartiles, and second, as a function of low E2 status and n-3 PUFA quartiles. Among HT non-users, positive, graded relationships (p-trends≤0.003) were found between PUFAs and incident depressive symptoms. Compared to the lowest quartile, the adjusted risk ratios (RRs) for the highest were 2.10, 2.39, and 2.04 for EPA, DHA, and EPA+DHA, respectively. For HT users, no associations were seen. When analyses were run for E2 status, the RRs over quartiles of the PUFAs were positive and graded for low E2 women, but were null for High E2 women. Higher intakes of DHA and EPA were associated with higher risk of depressive symptoms in nonusers of HT, contrary to hypothesis.
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影响因子：
4.2
作者：
Beydoun, May A.;Kuczmarski, Marie T. Fanelli;Zonderman, Alan B.
通讯作者：
Zonderman, Alan B.
DOI：
10.3109/13697137.2011.650656
发表时间：
2012-04
期刊：
Climacteric : the journal of the International Menopause Society
影响因子：
--
作者：
Harlow SD;Gass M;Hall JE;Lobo R;Maki P;Rebar RW;Sherman S;Sluss PM;de Villiers TJ;STRAW+10 Collaborative Group
通讯作者：
STRAW+10 Collaborative Group
影响因子：
4.2
作者：
Conner, Tamlin S.;Richardson, Aimee C.;Miller, Jody C.
通讯作者：
Miller, Jody C.
影响因子：
4.1
作者：
Crupi, R.;Marino, A.;Cuzzocrea, S.
通讯作者：
Cuzzocrea, S.
影响因子：
5.5
作者：
He K
通讯作者：
He K