The germfree state prevents development of gut and joint inflammatory disease in HLA-B27 transgenic rats.
The germfree state prevents development of gut and joint inflammatory disease in HLA-B27 transgenic rats.
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收获状态阻止了HLA-B27转基因大鼠中肠道和关节炎症性疾病的发展。
DOI：
10.1084/jem.180.6.2359
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发表时间：
1994-12-01
影响因子：
15.3
通讯作者：
Hammer, Robert E.
中科院分区：
文献类型：
--
作者：
Taurog, Joel D.;Richardson, James A.;Croft, Joanne T.;Simmons, William A.;Zhou, Ming;Fernandez-Sueiro, Jose Luis;Balish, Edward;Hammer, Robert E.
在遗传人类主要组织相容性复合体I类等位基因HLA-B27的个体中，许多炎症性疾病状态的发生频率大大增加。在少数病例中，即那些与b27相关的反应性关节炎，有充分的证据表明疾病状态是由肠道或泌尿生殖系统细菌病原体感染引发的。对于大多数b27相关疾病，尚未确定细菌的明确致病作用。然而，在后一种情况下，肠道炎症往往可以被证明，有时它占据了临床图片的主要部分。已知转基因B27的大鼠会出现一种类似于B27相关人类疾病的疾病，具有明显的肠道、关节、皮肤和男性生殖器炎症病变。我们在此报道，在无菌环境中饲养的B27转基因大鼠不会发生炎症性肠道或外周关节疾病，而皮肤和生殖器炎症病变不受无菌状态的影响。这些发现支持了肠道和关节炎症在病理上密切相关的概念，并为肠道菌群在b27相关肠道和关节炎症的发病机制中发挥重要作用提供了直接证据。
A number of inflammatory disease states occur with greatly increased frequency in individuals inheriting the human major histocompatibility complex class I allele HLA-B27. In a minority of cases, namely those with B27-associated reactive arthritis, there is good evidence that the disease state is triggered by infection with an enteric or genitourinary bacterial pathogen. For the majority of B27-associated disease, no definite pathogenetic role for bacteria has been established. However, in these latter cases intestinal inflammation can often be demonstrated, and it sometimes occupies a major part of the clinical picture. Rats transgenic for B27 are known to develop a disorder resembling B27-associated human disease, with prominent intestinal, joint, skin, and male genital inflammatory lesions. We report here that B27 transgenic rats raised in a germfree environment do not develop inflammatory intestinal or peripheral joint disease, whereas the skin and genital inflammatory lesions are unaffected by the germfree state. These findings support the concept that gut and joint inflammation are pathogenetically closely related, and they provide direct evidence that the commensal gut flora play an important role in the pathogenesis of B27-associated gut and joint inflammation.
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影响因子：
--
作者：
LEIRISALOREPO, M;TURUNEN, U;SEPPALA, K
通讯作者：
SEPPALA, K
影响因子：
3.1
作者：
STIMPSON, SA;BROWN, RR;SCHWAB, JH
通讯作者：
SCHWAB, JH
影响因子：
27.4
作者：
DEKKERSAEYS, BJ;MEUWISSEN, SGM;TYTGAT, GNJ
通讯作者：
TYTGAT, GNJ
DOI：
10.1084/jem.122.1.77
发表时间：
1965-07-01
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
SCHAEDLER RW;DUBS R;COSTELLO R
通讯作者：
COSTELLO R
影响因子：
64.5
作者：
HAMMER, RE;MAIKA, SD;TAUROG, JD
通讯作者：
TAUROG, JD