The effects of size, shape, and surface functional group of gold nanostructures on their adsorption and internalization by cells.
The effects of size, shape, and surface functional group of gold nanostructures on their adsorption and internalization by cells.
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DOI：
10.1002/smll.200901622
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发表时间：
2010-02-22
期刊：
影响因子：
13.3
通讯作者：
Xia, Younan
中科院分区：
文献类型：
--
作者：
Cho, Eun Chul;Au, Leslie;Zhang, Qiang;Xia, Younan
在这项研究中，我们研究了SK-BR-3乳腺癌细胞对金纳米结构的吸收（包括吸附和内化）的大小，形状和表面化学的影响。我们使用两种不同尺寸的球形和立方体Au纳米结构（分别为纳米球和纳米笼），并且它们的表面用聚（乙二醇）（PEG）、抗HER 2抗体或聚（烯丙胺盐酸盐）（PAA）修饰。我们的研究结果表明，Au纳米结构的大小以类似的方式影响细胞对它们的摄取，而不管表面化学性质如何，而形状依赖性可以根据表面官能团而变化。此外，细胞偏好以以下顺序摄取由不同表面基团覆盖的Au纳米结构：PAA>抗HER 2> PEG。附着在细胞表面的Au纳米结构的分数也取决于上述参数。
In this study, we examined the effects of size, shape, and surface chemistry of gold nanostructures on their uptake (including both adsorption and internalization) by SK-BR-3 breast cancer cells. We used both spherical and cubic Au nanostructures (nanospheres and nanocages, respectively) of two different sizes, and their surface was modified with poly(ethylene glycol) (PEG), antibody anti-HER2, or poly(allyamine hydrochloride) (PAA). Our results showed that the size of the Au nanostructures influenced their uptake by the cells in a similar way regardless of the surface chemistry, while the shape dependency could vary depending on the surface functional group. In addition, the cells preferred to take up the Au nanostructures covered by different surface groups in the following order: PAA>> anti-HER2> PEG. The fraction of Au nanostructures attached to the cell surface was also dependent on the aforementioned parameters.
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影响因子：
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影响因子：
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通讯作者：
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