3D Printing PDMS Elastomer in a Hydrophilic Support Bath via Freeform Reversible Embedding.
3D Printing PDMS Elastomer in a Hydrophilic Support Bath via Freeform Reversible Embedding.
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DOI：
10.1021/acsbiomaterials.6b00170
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发表时间：
2016-10-10
影响因子：
5.8
通讯作者：
Feinberg, Adam W.
中科院分区：
文献类型：
--
作者：
Hinton, Thomas J.;Hudson, Andrew;Pusch, Kira;Lee, Andrew;Feinberg, Adam W.
聚二甲基硅氧烷（PDMS）弹性体用于广泛的生物材料应用，包括微流体、细胞培养基质、柔性电子和医疗器械。然而，由于其低弹性模量和在打印过程中需要支撑，在复杂结构中3D打印PDMS具有挑战性。在这里，我们展示了通过自由形式可逆嵌入（FRE）在亲水性Carbopol凝胶支持物中3D打印疏水性PDMS预聚物树脂。在FRE打印过程中，Carbopol载体作为宾汉塑料，当3D打印机的注射器尖端移动通过它时，它会屈服并流化，但作为其中挤出的PDMS的固体。这与亲水Carbopol中疏水PDMS的不可渗透性相结合，将PDMS预聚物限制在载体内，固化时间长达72小时，同时保持尺寸稳定性。印刷和固化后，Carbopol支持凝胶通过使用磷酸盐缓冲盐水溶液释放嵌入的PDMS印刷品，以降低Carbopol屈服应力。作为概念验证，我们使用Sylgard 184 PDMS通过连续挤出3D打印线性和螺旋形长丝，并通过逐层制造3D打印圆柱形和螺旋形管。重要的是，我们证明了3D打印管是多方面的和可灌注的。结果表明，具有低粘度和长固化时间的疏水性聚合物可以使用亲水性支持物进行3D打印，从而扩大了可用于增材制造的生物材料的范围。此外，通过使用低成本开源硬件和软件工具来实现该技术，可以快速实现FRE打印技术以用于研究应用。
Polydimethylsiloxane (PDMS) elastomer is used in a wide range of biomaterial applications including microfluidics, cell culture substrates, flexible electronics, and medical devices. However, it has proved challenging to 3D print PDMS in complex structures due to its low elastic modulus and need for support during the printing process. Here we demonstrate the 3D printing of hydrophobic PDMS prepolymer resins within a hydrophilic Carbopol gel support via freeform reversible embedding (FRE). In the FRE printing process, the Carbopol support acts as a Bingham plastic that yields and fluidizes when the syringe tip of the 3D printer moves through it, but acts as a solid for the PDMS extruded within it. This, in combination with the immiscibility of hydrophobic PDMS in the hydrophilic Carbopol, confines the PDMS prepolymer within the support for curing times up to 72 h while maintaining dimensional stability. After printing and curing, the Carbopol support gel releases the embedded PDMS prints by using phosphate buffered saline solution to reduce the Carbopol yield stress. As proof-of-concept, we used Sylgard 184 PDMS to 3D print linear and helical filaments via continuous extrusion and cylindrical and helical tubes via layer-by-layer fabrication. Importantly, we show that the 3D printed tubes were manifold and perfusable. The results demonstrate that hydrophobic polymers with low viscosity and long cure times can be 3D printed using a hydrophilic support, expanding the range of biomaterials that can be used in additive manufacturing. Further, by implementing the technology using low cost open-source hardware and software tools, the FRE printing technique can be rapidly implemented for research applications.
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影响因子：
3.7
作者：
Palchesko RN;Zhang L;Sun Y;Feinberg AW
通讯作者：
Feinberg AW
影响因子：
13.6
作者：
Hinton TJ;Jallerat Q;Palchesko RN;Park JH;Grodzicki MS;Shue HJ;Ramadan MH;Hudson AR;Feinberg AW
通讯作者：
Feinberg AW
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