Phorate exposure and incidence of cancer in the agricultural health study.
Phorate exposure and incidence of cancer in the agricultural health study.
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在农业健康研究中，癌症的暴露和癌症发生率。
DOI：
10.1289/ehp.8911
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发表时间：
2006-08
影响因子：
10.4
通讯作者：
Alavanja MC
中科院分区：
文献类型：
--
作者：
Mahajan R;Bonner MR;Hoppin JA;Alavanja MC
我们最近在农业健康研究（AHS）中报道了有机磷农药甲拌磷的使用与前列腺癌家族史的施用者之间的联系。这一发现，以及其他有机磷农药和癌症之间的关联更广泛的发现，促使我们检查甲拌磷暴露和整体癌症发病率在AHS。增加3年的随访和使用更详细的暴露信息使我们能够看到前列腺癌的发现是否成立。AHS是对来自北卡罗来纳州和爱荷华州的许可限制使用农药施用者的前瞻性研究。据我们所知，这是对职业性接触甲拌磷的工人进行的最大规模的检查。使用1993年至1997年完成的两份自填问卷收集了农药暴露和其他信息。Poisson回归用于计算率比（RR）和95%置信区间（CI），调整潜在混杂因素。尽管我们没有足够的数量来研究非霍奇金淋巴瘤或白血病，但使用亚磷酸盐与所有癌症合并或任何单个癌症的发病率无关，这些癌症在其他研究中与有机磷有关。虽然前列腺癌的风险并没有显着相关的甲拌磷使用的整体或那些没有家族史，风险往往会增加与前列腺癌家族史的应用程序。交互作用RR为1.53（95%CI，0.99-2.37）。所观察到的统计学相互作用表明，在前列腺癌的发病率中，家族史和甲拌磷暴露之间存在基因-环境相互作用，但其他解释也是可能的。
We recently reported a link between use of the organophosphate pesticide phorate and risk of prostate cancer among applicators with a family history of prostate cancer in the Agricultural Health Study (AHS). This finding, together with findings of associations between other organophosphate pesticides and cancer more broadly, prompted us to examine phorate exposure and overall cancer incidence in the AHS. Adding 3 years of follow-up and using more detailed exposure information allowed us to see whether the prostate cancer finding held. The AHS is a prospective study of licensed restricted-use pesticide applicators from North Carolina and Iowa. To our knowledge, this is the largest examination of workers occupationally exposed to phorate. Pesticide exposure and other information was collected using two self-administered questionnaires completed from 1993 to 1997. Poisson regression was used to calculate rate ratios (RR) and 95% confidence intervals (CI), adjusting for potential confounders. Phorate use was not related to the incidence of all cancers combined or to any individual cancer, although we had insufficient numbers to study non-Hodgkin lymphoma or leukemia, which have been linked to organophosphates in other studies. Although prostate cancer risk was not significantly related to phorate use overall or among those without a family history, the risk tended to increase among applicators with a family history of prostate cancer. The interaction RR was 1.53 (95% CI, 0.99–2.37). The observed statistical interaction suggests a gene–environment interaction between family history and phorate exposure in the incidence of prostate cancer, but other explanations are also possible.
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影响因子：
2.1
作者：
Glover, FE;Coffey, DS;Walsh, PC
通讯作者：
Walsh, PC
影响因子：
--
作者：
Potti, Anil;Panwalkar, Amit W;Langness, Eric
通讯作者：
Langness, Eric
影响因子：
6.6
作者：
GRONBERG, H;DAMBER, L;DAMBER, JE
通讯作者：
DAMBER, JE
DOI：
10.1016/0165-1218(87)90095-4
发表时间：
1987-07-01
期刊：
MUTATION RESEARCH
影响因子：
--
作者：
LIN, MF;WU, CL;WANG, TC
通讯作者：
WANG, TC
影响因子：
5
作者：
Alavanja, MCR;Dosemeci, M;Blair, A
通讯作者：
Blair, A