Phylogenetic analysis of dengue virus reveals the high relatedness between imported and local strains during the 2013 dengue outbreak in Yunnan, China: a retrospective analysis.
Phylogenetic analysis of dengue virus reveals the high relatedness between imported and local strains during the 2013 dengue outbreak in Yunnan, China: a retrospective analysis.
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登革热病毒的系统发育分析揭示了2013年中国云南登革热疫情期间进口毒株与本地毒株之间的高度相关性：回顾性分析
DOI：
10.1186/s12879-015-0908-x
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发表时间：
2015-03-21
影响因子：
3.7
通讯作者：
Xia X
中科院分区：
文献类型：
--
作者：
Wang B;Li Y;Feng Y;Zhou H;Liang Y;Dai J;Qin W;Hu Y;Wang Y;Zhang L;Baloch Z;Yang H;Xia X
研究背景云南省发生了登革病毒（DENV）暴发疫情。2013年8月至11月，2 000多人感染。本研究通过对云南省德宏州登革病毒（DENV）分离株的系统发育和进化分析，探讨德宏州登革病毒的起源和流行特征。对登革病毒E基因进行了扩增和序列测定。不同基因型的分布和进化特征阐明了系统发育和Bayesian analysis.ResultsPhylogenetically，所有的41例登革病毒阳性样本可分为基因型I（43.9%）的血清型DENV-1和亚洲I型（56.1%）的血清型DENV-2。来自本地患者和外国旅行者的DENV菌株均匀地分散在这两个集群中。结论2013年登革热暴发流行期间，输入毒株与本地毒株具有高度的相关性。此外，这些数据可能表明，这次登革热疫情是由邻国缅甸新输入的感染引起的。
BackgroundAn outbreak of dengue virus (DENV) occurred in Yunnan province. More than 2,000 individuals were infected from August to November 2013. In this study, we aimed to characterize the origin and prevalence of DENV in Dehong prefecture of Yunnan province using phylogenetic and evolutionary analyses of DENV strains collected from local patients and foreign travelers.MethodsA total of 41 DENV-positive serum samples were randomly collected from travelers who entered China at Ruili port or local patients with dengue fever in Dehong prefecture of Yunnan province, China. The envelope (E) gene of DENV was amplified and sequenced. The distributions and evolutionary characteristics of different genotypes were elucidated by phylogenetic and Bayesian analyses.ResultsPhylogenetically, all of the 41 DENV-positive samples could be classified into genotype I (43.9%) of serotype DENV-1 and the Asian I genotype (56.1%) of serotype DENV-2. DENV strains derived from local patients and foreign travelers were scattered equally within these two clusters. Furthermore, the DENV strains from the two populations exhibited high relatedness based on evolutionary characteristics.ConclusionsThese results suggested that imported and local DENV strains occurring during the dengue outbreak in 2013 were highly related. Additionally, these data may suggest that this dengue outbreak was caused by a newly imported infection from the neighboring country of Myanmar.
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影响因子：
4.8
作者：
Ma X;Zhen W;Yang P;Sun X;Nie W;Zhang L;Xu H;Hu K
通讯作者：
Hu K
影响因子：
1.7
作者：
Luo, Lei;Liang, Hui-ying;Yang, Zhi-cong
通讯作者：
Yang, Zhi-cong
DOI：
10.1089/vbz.2008.0187
发表时间：
2009-06
期刊：
Vector borne and zoonotic diseases (Larchmont, N.Y.)
影响因子：
--
作者：
Roca Y;Baronti C;Revollo RJ;Cook S;Loayza R;Ninove L;Fernandez RT;Flores JV;Herve JP;de Lamballerie X
通讯作者：
de Lamballerie X
影响因子：
5
作者：
Aquino, Jose D. J. Diaz;Tang, Wei-Feng;Makino, Yoshihiro
通讯作者：
Makino, Yoshihiro
影响因子：
3.7
作者：
Romano CM;de Matos AM;Araújo ES;Villas-Boas LS;da Silva WC;Oliveira OM;Carvalho KI;de Souza AC;Rodrigues CL;Levi JE;Kallas EG;Pannuti CS
通讯作者：
Pannuti CS