Phylogenetic diversity and genotypical complexity of H9N2 influenza A viruses revealed by genomic sequence analysis.
Phylogenetic diversity and genotypical complexity of H9N2 influenza A viruses revealed by genomic sequence analysis.
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DOI：
10.1371/journal.pone.0017212
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发表时间：
2011-02-28
期刊：
影响因子：
3.7
通讯作者：
He H
中科院分区：
文献类型：
--
作者：
Dong G;Luo J;Zhang H;Wang C;Duan M;Deliberto TJ;Nolte DL;Ji G;He H
H9 N2甲型流感病毒已在世界范围内的陆生家禽和野鸟中建立，偶尔也会传播给包括人类和猪在内的哺乳动物。为了全面阐明H9 N2流感病毒的遗传和进化特征，我们对NCBI流感病毒资源数据库中的571个病毒基因组进行了大规模的序列分析，这些基因组代表了1966年至2009年分离的H9 N2流感病毒谱。我们的研究为更好地理解H9 N2流感病毒的起源和进化以及描述H9 N2病毒在不同宿主中传播的历史提供了一个全景框架。对H9 N2亚型流感病毒8个基因片段的系统发育分析揭示了H9 N2亚型流感病毒的复杂性和多样性。571个H9 N2病毒基因组被分为74个独立的谱系，这些谱系具有明显的宿主和地理遗传差异。Panorama基因型分析还显示，H9 N2病毒包括至少98种基因型，根据其HA谱系进一步分为7个系列（A-G）。内部基因的系统发育分析表明，H9 N2病毒与H3、H4、H5、H7、H10和H14亚型流感病毒密切相关。我们的研究结果表明，H9 N2病毒已经经历了广泛的重组，产生多种重组子和基因型，这表明，在世界各地的不同宿主中，多种基因型H9 N2病毒的持续传播有可能导致未来的禽流感暴发和人类流行。我们提出了一个命名系统，以确定和统一的所有谱系和基因型的H9 N2流感病毒，以促进国际交流的进化，生态学和流行病学的H9 N2流感病毒。
H9N2 influenza A viruses have become established worldwide in terrestrial poultry and wild birds, and are occasionally transmitted to mammals including humans and pigs. To comprehensively elucidate the genetic and evolutionary characteristics of H9N2 influenza viruses, we performed a large-scale sequence analysis of 571 viral genomes from the NCBI Influenza Virus Resource Database, representing the spectrum of H9N2 influenza viruses isolated from 1966 to 2009. Our study provides a panoramic framework for better understanding the genesis and evolution of H9N2 influenza viruses, and for describing the history of H9N2 viruses circulating in diverse hosts. Panorama phylogenetic analysis of the eight viral gene segments revealed the complexity and diversity of H9N2 influenza viruses. The 571 H9N2 viral genomes were classified into 74 separate lineages, which had marked host and geographical differences in phylogeny. Panorama genotypical analysis also revealed that H9N2 viruses include at least 98 genotypes, which were further divided according to their HA lineages into seven series (A–G). Phylogenetic analysis of the internal genes showed that H9N2 viruses are closely related to H3, H4, H5, H7, H10, and H14 subtype influenza viruses. Our results indicate that H9N2 viruses have undergone extensive reassortments to generate multiple reassortants and genotypes, suggesting that the continued circulation of multiple genotypical H9N2 viruses throughout the world in diverse hosts has the potential to cause future influenza outbreaks in poultry and epidemics in humans. We propose a nomenclature system for identifying and unifying all lineages and genotypes of H9N2 influenza viruses in order to facilitate international communication on the evolution, ecology and epidemiology of H9N2 influenza viruses.
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影响因子：
5.4
作者：
Guan, Y;Shortridge, KF;Peiris, M
通讯作者：
Peiris, M
影响因子：
3.8
作者：
Brown, IH;Ludwig, S;Alexander, DJ
通讯作者：
Alexander, DJ
DOI：
10.1073/pnas.160270697
发表时间：
2000-08-15
影响因子：
11.1
作者：
Lin, YP;Shaw, M;Hay, A
通讯作者：
Hay, A
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3.3
作者：
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通讯作者：
Alexander, DJ
影响因子：
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作者：
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通讯作者：
Kida, H