Investigating the impact of a CAPRIN1 condensate solvent on the conformational equilibrium and activity of the CNOT7 deadenylase

研究 CAPRIN1 缩合溶剂对 CNOT7 去腺苷酶构象平衡和活性的影响

• 批准号: 441074
• 负责人: Rangadurai Atul Kaushik
• 金额: $ 9.83万
• 依托单位: Hospital for Sick Children (Toronto)
• 依托单位国家: 加拿大
• 项目类别: Fellowship Programs
• 财政年份: 2020
• 资助国家: 加拿大
• 起止时间: 2020-12-01 至 2023-12-01
• 项目状态: 已结题
• 来源: https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=441074&lang=en
• 关键词: Biomolecular Condensates; Biomolecular Structure And Dynamics; Caprin1; Cnot7; Deadenylation; Enzyme Kinetics; Mrna Processing; Nuclear Magnetic Resonance Spectroscopy; Phase Separation

Understanding how machines such as cars work requires us to know the components that comprise them and how they interact with each other to ultimately perform the desired function, which in the case of cars is transportation. In an analogous manner, our b

要理解像汽车这样的机器是如何工作的，我们需要知道组成它们的组件以及它们如何相互作用以最终执行所需的功能，在汽车的情况下是运输。以类似的方式，我们的B