Elucidating the genetic basis of newly evolved metabolic functions in yeast

阐明酵母新进化代谢功能的遗传基础

• 批准号: LP160100610
• 负责人: Dr Richard Edwards
• 金额: $ 22.57万
• 依托单位: The University of New South Wales
• 依托单位国家: 澳大利亚
• 项目类别: Linkage Projects
• 财政年份: 2016
• 资助国家: 澳大利亚
• 起止时间: 2016-08-25 至 2020-08-24
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/LP160100610
• 关键词: Elucidating; genetic; basis; newly; evolved

Elucidating the genetic basis of newly evolved metabolic functions in yeast. This project intends to research how complex metabolic pathways originate and evolve. This project will use cutting edge genome sequencing and molecular techniques to elucidate the heritable genetic basis of Baker’s yeast, which has been the selectively evolved to use xylose as a sole carbon source: something vital for second generation biofuel production that wild yeast cannot do. This project will combine detailed molecular characterisation of highly adapted yeast strains with a novel "molecular palaeontology" approach to trace the evolutionary process and identify functionally significant loci under selection. Detailed characterisation of this trait will accelerate the development of future yeast strains and test fundamental evolutionary theories.

阐明酵母新进化代谢功能的遗传基础。该项目旨在研究复杂的代谢途径如何起源和演变。该项目将使用最先进的基因组测序和分子技术来阐明面包酵母的遗传基础，面包酵母已经选择性地进化为使用木糖作为唯一的碳源：这对第二代生物燃料生产至关重要，而野生酵母不能做到。该项目将结合联合收割机详细的分子特征的高度适应的酵母菌株与一种新的“分子古生物学”的方法来跟踪进化过程，并确定功能显着的基因座选择。对这一特性的详细描述将加速未来酵母菌株的开发，并测试基本的进化理论。