Acquisition of an X-ray Diffractometer and Area Detector

将获得一台x射线衍射仪和面积探测器。各种各样的生物项目将得到新设备的支持。获得资助的项目包括：对疏水植物蛋白豆状蛋白的进一步研究；毒硫素，一种来自小麦的溶血毒素；Kringle 4，纤溶酶原的片段；藻蓝蛋白，一种光收集天线细菌蛋白；突变的天冬氨酸转甲氨基酰基酶，一种在嘧啶代谢中很重要的酶；天然产物;有机分子合成受体；金属离子配合物与核酸；金属离子与辅酶结合。这些小分子和其他大分子的晶体学研究将与许多其他技术相结合，如CD，拉曼，核磁共振和ESR光谱；平衡结合测定和酶动力学；有机合成;计算机图形学、分子力学和结构预测。总的来说，目的是研究结构与功能之间的关系，将静态结构信息与动态信息相结合，从而更全面地了解大分子的功能。晶体结构测定也将作为天然产物有机合成和合成受体设计的重要辅助手段。

An x-ray diffractometer and area detector will be acquired. A wide variety of biological projects will be supported by the new equipment. Among the projects to be supported are further studies on crambin, a hydrophobic plant protein; purothionin, a hemolytic toxin from wheat; kringle 4, a fragment of the enzyme plasminogen; phycocyanin, a light harvesting antenna bacterial protein; and mutant aspartate transcarbamylases, an enzyme important in pyrimidine metabolism; natural products; synthetic receptors for organic molecules; metal ion complexes with nucleic acids; metal ions bound to coenzymes. These crystallographic studies on small molecules and other macromolecules will be combined with numerous other techniques such as CD, Raman, NMR and ESR spectroscopy; equilibrium binding assays and enzymatic kinetics; organic synthesis; computer graphics and molecular mechanics and structural prediction. On the whole, the intent is to look at structure-function relationships, integrating static structural information with dynamic information to gain a more complete understanding of macromolecular function. The crystallographic structural determination will also serve as an important adjunct to organic synthesis of natural products and to the design of synthetic receptors.