Acquisition of an X-ray Diffractometer and Area Detector

获取 X 射线衍射仪和区域探测器

• 批准号: 8617930
• 负责人: Martha Teeter
• 金额: $ 33.03万
• 依托单位: Boston College
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 1987
• 资助国家: 美国
• 起止时间: 1987-09-15 至 1991-05-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=8617930&HistoricalAwards=false
• 关键词: Acquisition; ray; Diffractometer; Area; Detector

An x-ray diffractometer and area detector will be acquired. A wide variety of biological projects will be supported by the new equipment. Among the projects to be supported are further studies on crambin, a hydrophobic plant protein; purothionin, a hemolytic toxin from wheat; kringle 4, a fragment of the enzyme plasminogen; phycocyanin, a light harvesting antenna bacterial protein; and mutant aspartate transcarbamylases, an enzyme important in pyrimidine metabolism; natural products; synthetic receptors for organic molecules; metal ion complexes with nucleic acids; metal ions bound to coenzymes. These crystallographic studies on small molecules and other macromolecules will be combined with numerous other techniques such as CD, Raman, NMR and ESR spectroscopy; equilibrium binding assays and enzymatic kinetics; organic synthesis; computer graphics and molecular mechanics and structural prediction. On the whole, the intent is to look at structure-function relationships, integrating static structural information with dynamic information to gain a more complete understanding of macromolecular function. The crystallographic structural determination will also serve as an important adjunct to organic synthesis of natural products and to the design of synthetic receptors.

将获得一台X射线衍射仪和面积探测器。新设备将支持各种各样的生物项目。将得到支持的项目包括：疏水性植物蛋白Crambin；小麦溶血毒素purothiin；纤溶酶原片段kringle 4；捕光天线细菌蛋白藻蓝蛋白；突变的天冬氨酸氨基转移酶，一种在嘧啶代谢中起重要作用的酶；天然产品；有机分子的合成受体；金属离子与核酸的络合物；与辅酶结合的金属离子。这些对小分子和其他大分子的结晶学研究将与许多其他技术相结合，如CD、拉曼、核磁共振和ESR光谱；平衡结合分析和酶动力学；有机合成；计算机图形学和分子力学和结构预测。总体而言，其目的是观察结构与功能的关系，将静态结构信息与动态信息相结合，以获得对大分子功能的更完整的理解。晶体结构测定也将作为天然产物有机合成和合成受体设计的重要辅助手段。