New Reactions for Organic Synthesis

有机合成新反应

• 批准号: 8618451
• 负责人: Larry Overman
• 金额: $ 39.96万
• 依托单位: University of California-Irvine
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 1987
• 资助国家: 美国
• 起止时间: 1987-05-01 至 1990-10-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=8618451&HistoricalAwards=false
• 关键词: New; Reactions; Organic; Synthesis

The general objective of this program is to develop new chemical reactions and synthesis strategies that will allow complex organic chemicals to be synthesized efficiently. As a result of the central importance of carbon in organic chemistry,our studies focus on the development of new selective (chemo-,regio-, and stereoselective) methods for forming carbon-carbon bonds. The studies proposed are broad in scope and encompass both mechanistic studies aimed at developing a fundamental understanding of chemical reactivity and total synthesis studies aimed at exploring the utility of the reactions we are developing for the preparation of specific complex target structures. The majority of our efforts during the proposed project period will focus on developing new cyclization reactions to prepare medium ring heterocycles and carbocycles. Of all the types of ring systems (small, common, medium and large) existing methods are least satisfactory for preparing medium rings. Our studies are based on an important discovery made during the current grant period that medium ring ethers can be formed efficiently by simple acetal-alkene cyclizations. Other investigations will focus on developing new methods to prepare monocyclic b-lactams in enantiomerically pure form. We will also continue our collaborative computational and experimental investigations to develop new models for predicting regio- and stereoselectivity in Diels-Adler reactions of highly functionalized cycloaddition components.

该计划的总体目标是开发新的化学品 反应和合成策略，使复杂的有机 化学品要高效合成。 由于中央 碳在有机化学中的重要性，我们的研究重点是 开发新的选择性（化学、区域和立体选择性） 形成碳-碳键的方法。拟议的研究包括 范围广泛，包括旨在 发展对化学反应性的基本理解， 全合成研究旨在探索的效用， 我们正在开发的用于制备特定复合物的反应 目标结构。 在拟议项目期间，我们的大部分工作将 重点开发新的环化反应制备中环 杂环和碳环。 在所有类型的星环系统中 （小型、普通、中型和大型）现有方法最少 适合于制备中等环。 我们的研究是基于 在目前的资助期内， 简单的缩醛-烯烃可以有效地形成环醚， 循环 其他调查将集中在开发新的 制备对映体纯形式的单环β-内酰胺的方法。 我们还将继续我们的合作计算和实验 研究开发新的预测区域和 高度官能化Diels-Adler反应的立体选择性 环加成组分。