New Methods for Asymmetric Synthesis of Valuable Chemicals

有价值化学品的不对称合成新方法

• 批准号: 0200786
• 负责人: Larry Overman
• 金额: $ 63.5万
• 依托单位: University of California-Irvine
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-02-01 至 2006-01-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0200786&HistoricalAwards=false
• 关键词: New; Methods; Asymmetric; Synthesis; Valuable

The focus of this research is the development of asymmetric methods for activating carbon-carbon pi-bonds for attack by external nucleophiles and for the stereospecific cross-coupling reactions of stereogenic secondary carbon centers will be developed. In the former, Pd(II)-catalyzed processes will be used to develop both carbon-heteroatom and carbon-carbon bond-forming reactions. In the latter, palladacyclic intermediates containing Pd sigma-bonded to a stereogenic secondary carbon will be used to develop the reaction chemistry for stereospecific catalytic cross-coupling of stereogenic secondary carbons. With this renewal award, the Organic and Macromolecular Chemistry Program is supporting the research efforts of Dr. Larry E. Overman in the Department of Chemistry at the University of California, Irvine. Professor Overman will focus his work on developing catalytic, asymmetric reactions for the formation of carbon-carbon and carbon-heteroatom bonds. The research has broad implications for the environment by minimizing the production of chemical wastes and resulting methodology could be of great interest to the pharmaceutical and agricultural industries. This area of research has proven to be a valuable setting for the training of undergraduate, graduate and post-doctoral students.

本研究的重点是开发用于活化碳-碳π键以供外部亲核试剂攻击的不对称方法，并将开发用于立体异构仲碳中心的立体定向交叉偶联反应的不对称方法。在前者中，Pd（II）催化的过程将用于开发碳-杂原子和碳-碳键形成反应。 在后者中，含有Pd σ-键合到立体仲碳的钯环中间体将用于开发立体仲碳的立体特异性催化交叉偶联的反应化学。 有了这个更新奖，有机和高分子化学计划是支持博士的研究工作。欧文市加州大学化学系的奥弗曼说。 奥弗曼教授将把工作重点放在开发用于形成碳-碳键和碳-杂原子键的催化、不对称反应上。 该研究通过最大限度地减少化学废物的产生对环境产生了广泛的影响，由此产生的方法可能对制药和农业行业产生极大的兴趣。 这一研究领域已被证明是培养本科生，研究生和博士后学生的宝贵环境。