New Methods for Synthesis of Complex Chemicals

9412266 Overman本研究的重点将是通过新的环化方法合成立体化学复杂的氧和氮杂环，并开发用于3，3-sigmatropic重排的不对称催化的一般方法。 5种海洋天然产物Ptilomycalin A、crambescidin 800、isocrambescidin 800、manzamine A和（E）-pinnatifidenyne是其特异性的合成目标。 有了这个更新的奖项，合成有机计划是支持博士拉里E。欧文市加州大学化学系的奥弗曼说。 奥弗曼教授将把他的工作重点放在复杂有机分子合成的经济方法的发展上。 该方法预计将影响制药、农业和材料行业的发现、开发和生产部分。 ***

9412266 Overman The focus of this research will be on the synthesis of stereochemically complex oxygen and nitrogen heterocycles by new cyclization methods and on the development of a general method for asymmetric catalysis of 3,3 -sigmatropic rearrangements. Five marine natural products, ptilomycalin A, crambescidin 800, isocrambescidin 800, manzamine A and (E)-pinnatifidenyne are the specific synthetic targets. %%% With this renewal award, the Synthetic Organic Program is supporting the research of Dr. Larry E. Overman of the Department of Chemistry at the University of California, Irvine. Professor Overman will focus his work on the development of economical methods for the synthesis of complex organic molecules. The approach is expected to impact the discovery, development and production components of the pharmaceutical, agricultural and materials industries. ***