New Methods for Asymmetric Synthesis of Valuable Chemicals
New Methods for Asymmetric Synthesis of Valuable Chemicals
批准号:
9726471
负责人:
Larry Overman
金额:
$64.43万
依托单位国家:
美国
项目类别:
Continuing Grant
财政年份:
1997
资助国家:
美国
项目状态:
已结题
起止时间:
1997-12-01 至 2001-11-30
中文摘要
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英文摘要
The focus of this research is the development of methodology for the construction of a variety of C-X bonds: C-C, C-N and C-O. The majority of the effort will be be spent developing methods for catalytic asymmetric activation of alkenes for attack by non-metal bound, external nucleophiles. To this end, the synthesis of a variety of novel planar chiral Pd(II) catalysts will be carried out. The reactions targeted for catalysis include allylic imidate rearrangements, Cope and Claisen rearrangements, allylic ester rearrangements and cyclizations to form chiral nitrogen and oxygen containing heterocycles. A second aspect of the research focuses on the asymmetric Heck reaction. The objective of all of the investigations is to develop practical catalytic methods through systematic studies that will provide fundamental insight that will enable future rational development of new asymmetric catalyst architectures. With this renewal award, the Organic and Macromolecular Chemistry Program is supporting the research of Dr. Larry E. Overman of the Department of Chemistry at the University of California, Irvine. Professor Overman will focus his work on developing new catalytic asymmetric transformations of inexpensive alkenes to valuable enantiopure products. The development of this type of methodology is of great importance to the pharmaceutical industry.
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New Approaches for Stereoselective Formation of Quaternary Carbon Stereocenters and Fragment Coupling
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批准号:1661612
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项目类别:Continuing Grant
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资助金额:$54.0万
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财政年份:2017
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负责人:Larry Overman
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依托单位:
New Approaches for Stereoselective Formation of Quaternary Carbon Stereocenters and Fragment Coupling
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批准号:1265964
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项目类别:Continuing Grant
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资助金额:$62.99万
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财政年份:2013
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负责人:Larry Overman
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依托单位:
New Methods for Catalytic Asymmetric Synthesis of Valuable Chemicals
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批准号:0616201
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项目类别:Continuing Grant
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资助金额:$0.0万
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财政年份:2006
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负责人:Larry Overman
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依托单位:
New Methods for Asymmetric Synthesis of Valuable Chemicals
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批准号:0200786
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项目类别:Continuing Grant
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资助金额:$63.5万
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财政年份:2002
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负责人:Larry Overman
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依托单位:
New Methods for Synthesis of Complex Chemicals
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批准号:9412266
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项目类别:Continuing Grant
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资助金额:$51.62万
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财政年份:1994
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负责人:Larry Overman
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依托单位:
Purchase of X-Ray Crystallographic Equipment
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批准号:9300266
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项目类别:Standard Grant
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资助金额:$20.05万
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财政年份:1993
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负责人:Larry Overman
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依托单位:
New Reactions for Organic Synthesis
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批准号:9003812
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项目类别:Continuing Grant
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资助金额:$42.43万
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财政年份:1990
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负责人:Larry Overman
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依托单位:
Purchase of a Quadrupole Mass Spectrometer
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批准号:9014776
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项目类别:Standard Grant
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资助金额:$22.62万
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财政年份:1990
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负责人:Larry Overman
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依托单位:
Research Experiences for Undergraduates in Chemistry at the University of California, Irvine
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批准号:9000825
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项目类别:Continuing Grant
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资助金额:$11.92万
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财政年份:1990
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负责人:Larry Overman
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依托单位:
New Reactions for Organic Synthesis
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批准号:8618451
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项目类别:Continuing Grant
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资助金额:$39.96万
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财政年份:1987
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负责人:Larry Overman
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依托单位:
New Reactions for Organic Synthesis (Chemistry)
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批准号:8203366
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项目类别:Continuing Grant
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资助金额:$54.79万
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财政年份:1982
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负责人:Larry Overman
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依托单位:
New Synthetic Reactions
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批准号:7901833
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项目类别:Continuing Grant
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资助金额:$18.08万
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财政年份:1979
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负责人:Larry Overman
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依托单位:
New Synthetic Reactions
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批准号:7606101
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项目类别:Continuing Grant
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资助金额:$12.58万
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财政年份:1976
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负责人:Larry Overman
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依托单位:
New Stereospecific and Regiospecific Intracomplex and Intramolecular Synthetic Reactions
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批准号:7308759
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项目类别:Continuing Grant
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资助金额:$3.41万
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财政年份:1973
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负责人:Larry Overman
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依托单位:
国内基金
海外基金
Computational Methods for Analyzing Toponome Data
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批准号:60601030
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项目类别:青年科学基金项目
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资助金额:17.0万元
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批准年份:2006
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负责人:Axel Mosig
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依托单位: