New Methods for Asymmetric Synthesis of Valuable Chemicals

有价值化学品的不对称合成新方法

• 批准号: 9726471
• 负责人: Larry Overman
• 金额: $ 64.43万
• 依托单位: University of California-Irvine
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-12-01 至 2001-11-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9726471&HistoricalAwards=false
• 关键词: New; Methods; Asymmetric; Synthesis; Valuable

The focus of this research is the development of methodology for the construction of a variety of C-X bonds: C-C, C-N and C-O. The majority of the effort will be be spent developing methods for catalytic asymmetric activation of alkenes for attack by non-metal bound, external nucleophiles. To this end, the synthesis of a variety of novel planar chiral Pd(II) catalysts will be carried out. The reactions targeted for catalysis include allylic imidate rearrangements, Cope and Claisen rearrangements, allylic ester rearrangements and cyclizations to form chiral nitrogen and oxygen containing heterocycles. A second aspect of the research focuses on the asymmetric Heck reaction. The objective of all of the investigations is to develop practical catalytic methods through systematic studies that will provide fundamental insight that will enable future rational development of new asymmetric catalyst architectures. With this renewal award, the Organic and Macromolecular Chemistry Program is supporting the research of Dr. Larry E. Overman of the Department of Chemistry at the University of California, Irvine. Professor Overman will focus his work on developing new catalytic asymmetric transformations of inexpensive alkenes to valuable enantiopure products. The development of this type of methodology is of great importance to the pharmaceutical industry.

本研究的重点是发展的方法， 各种C-X键的构建：C-C，C-N和C-O。 大多数 的努力将用于开发催化方法， 烯烃的不对称活化，用于非金属键合的外部攻击 亲核试剂 为此，合成了多种新颖的平面 将进行手性Pd（II）催化剂。 反应目标为 催化包括烯丙酰亚胺重排，科普和克莱森 重排、烯丙基酯重排和环化以形成 含手性氮和氧的杂环。 的第二方面 研究的重点是不对称Heck反应。 的目标 所有的研究都是为了开发实用的催化方法 通过系统的研究，将提供基本的见解， 将使未来合理开发新型不对称催化剂成为可能 建筑 有了这个更新奖，有机和高分子 化学计划是支持博士拉里E。奥弗曼 加州大学欧文分校化学系。 奥弗曼教授将致力于开发新的催化剂 廉价烯烃到有价值的对映体纯的不对称转化 产品. 这类方法的发展具有重大意义 对制药业的重要性。