New Methods for Asymmetric Synthesis of Valuable Chemicals

这项研究的重点是发展各种C-X键的构建方法：C-C、C-N和C-O。大部分工作将用于开发烯烃的催化不对称活化方法，以应对非金属结合的外部亲核试剂的攻击。为此，将开展各种新型平面手性Pd(II)催化剂的合成。催化反应包括烯丙基酰亚胺重排、Cope和Claisen重排、烯丙基酯重排和环化反应，形成手性含氮和含氧杂环。研究的第二个方面是不对称Heck反应。所有这些研究的目的都是通过系统的研究来开发实用的催化方法，这些方法将为未来合理开发新的不对称催化剂结构提供基础的见解。通过这个续展奖项，有机和高分子化学项目支持加州大学欧文分校化学系的拉里·E·奥弗曼博士的研究。奥弗曼教授将专注于开发廉价烯烃的新催化不对称转化为有价值的对映体产品。这类方法学的发展对制药行业具有重要意义。

The focus of this research is the development of methodology for the construction of a variety of C-X bonds: C-C, C-N and C-O. The majority of the effort will be be spent developing methods for catalytic asymmetric activation of alkenes for attack by non-metal bound, external nucleophiles. To this end, the synthesis of a variety of novel planar chiral Pd(II) catalysts will be carried out. The reactions targeted for catalysis include allylic imidate rearrangements, Cope and Claisen rearrangements, allylic ester rearrangements and cyclizations to form chiral nitrogen and oxygen containing heterocycles. A second aspect of the research focuses on the asymmetric Heck reaction. The objective of all of the investigations is to develop practical catalytic methods through systematic studies that will provide fundamental insight that will enable future rational development of new asymmetric catalyst architectures. With this renewal award, the Organic and Macromolecular Chemistry Program is supporting the research of Dr. Larry E. Overman of the Department of Chemistry at the University of California, Irvine. Professor Overman will focus his work on developing new catalytic asymmetric transformations of inexpensive alkenes to valuable enantiopure products. The development of this type of methodology is of great importance to the pharmaceutical industry.