New Reactions for Organic Synthesis

这项研究是由有机合成计划资助的。奥弗曼博士将继续开发新的成环反应，特别是集中在中等成环范围。这将提供农业和工业日益复杂的需求所需的一些新工具。本项目的研究主要集中在两个方面：(1)开发新的环化反应以形成中间环。在所有类型的环(小的、普通的、中的和大的)中，现有的方法对于制备中的环最不令人满意。(2)发展亲核剂促进的亲电环化反应。这类反应是最近发现的，有望极大地扩大简单炔烃在化学合成中的应用。

This research is being funded by the Organic Synthesis Program. Dr. Overman will continue his development of new ring forming reactions, particularly focussing on the medium ring range. This will provide some of the new tools required by the increasingly complex demands of agriculture and industry. The studies for the project focus in two areas: (1) Developing new cyclization reactions for forming medium rings. Of all types of rings (small, common, medium and large) existing methods are least satisfactory for preparing medium rings. (2) Developing electrophilic cyclization reactions that are promoted by nucleophiles. Reactions of this type were recently discovered and hold exciting promise for greatly expanding the utility of simple alkynes in chemical synthesis.