Electrochemical Amination Reactions for Amino Acid Synthesis

氨基酸合成的电化学胺化反应

• 批准号: 8660140
• 负责人: Anthony Sammells
• 金额: $ 4万
• 依托单位: Eltron Research, Inc.
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 1987
• 资助国家: 美国
• 起止时间: 1987-02-01 至 1987-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=8660140&HistoricalAwards=false
• 关键词: Electrochemical; Amination; Reactions; Amino; Acid

The purpose of this endeavor is to develop an efficient electrochemical process for the commercial production of amino acids. The PI plans to use electrochemically generated homogeneous catalysts to produce dl-dopa and dl-phenylalanine. These products are used respectively in the preparation of the artificial sweetener Nutrasweet and in the treatment of Parkinson's disease. The experimental program planned is directed towards gaining insight into electrochemical reaction mechanisms involved in the amino acid sythesis. Electrochemical processes may possess the following advantages: (1) provide greater selectivity than an equivalent chemical process; (2) be environmentally more benign; and (3) provide the opportunity for a simplified overall industrial process where one or more steps normally found in conventional chemical processes can be avoided. This project could also increase overall understnading of electrolytic cells. The PI has broad experience in electrochemistry and the company has the equipment to perform the proposed work. Funding of this Phase I is recommended.

这一努力的目的是为氨基酸的商业生产开发一种高效的电化学工艺。PI计划使用电化学产生的均相催化剂来生产dl-多巴和dl-苯丙氨酸。这些产品分别用于人工甜味剂纽崔斯甜的制备和帕金森病的治疗。计划的实验计划旨在深入了解氨基酸合成中涉及的电化学反应机理。电化学过程可能具有以下优点：(1)提供比同等化学过程更高的选择性；(2)对环境更无害；(3)提供简化的整个工业过程的机会，其中可以避免常规化学过程中通常存在的一个或多个步骤。该项目还可以增加对电解槽的整体了解。PI在电化学方面有丰富的经验，该公司拥有执行拟议工作的设备。建议为这一阶段提供资金。