Regulation of the Protein Glycosylation Pathway in Yeast

酵母中蛋白质糖基化途径的调控

• 批准号: 8703141
• 负责人: Clinton Ballou
• 金额: $ 17.88万
• 依托单位: University of California-Berkeley
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 1987
• 资助国家: 美国
• 起止时间: 1987-08-01 至 1991-01-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=8703141&HistoricalAwards=false
• 关键词: Regulation; Protein; Glycosylation; Pathway; Yeast

Regulation of the Protein Glycosylation Pathway in Yeast: Dr. Ballou has mutants of yeast that affect the regulation of mannoprotein synthesis. He will use each of these to clarify an aspect of function and regulation of protein glycosylation. The first mutant will be used to determine the role of glucose units on the lipid-linked oligosaccharide precursor; the second to study the regulation of the length of the mannoprotein outer chain and the third will be used to study branching of the outer chain. Saccharomyces cerevisiae, common yeast, provides a useful model for studies on eucaryotic development and on the structure function relationships of the carbohydrate component of glycoproteins. This work should lead to a better understanding of the developmental role of these compounds. Yeasts are important in biotechnology and the results of these studies may form the basis for developing new useful strains.

酵母中蛋白质糖基化途径的调节：Ballou 博士拥有影响甘露糖蛋白合成调节的酵母突变体。 他将利用其中的每一个来阐明蛋白质糖基化的功能和调节的一个方面。 第一个突变体将用于确定葡萄糖单元对脂质连接寡糖前体的作用；第二个用于研究甘露糖蛋白外链长度的调节，第三个将用于研究外链的分支。 酿酒酵母（Saccharomyces cerevisiae）是常见的酵母，为研究真核发育和糖蛋白碳水化合物成分的结构功能关系提供了有用的模型。 这项工作应该有助于更好地了解这些化合物的发育作用。 酵母在生物技术中很重要，这些研究的结果可能构成开发新的有用菌株的基础。