ASM Conference on DNA Replication and Mutagenesis, November 12-18, l987, Marco Island, FL

ASM DNA 复制和突变会议，1987 年 11 月 12 日至 18 日，佛罗里达州马可岛

• 批准号: 8704342
• 负责人: Robb Moses
• 金额: --
• 依托单位: American Society For Microbiology
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 1987
• 资助国家: 美国
• 起止时间: 1987-10-01 至 1988-03-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=8704342&HistoricalAwards=false
• 关键词: ASM; Conference; DNA; Replication; Mutagenesis

This meeting will bring together workers in the areas of DNA replication and mutagenesis for a combined meeting focusing on the events of DNA replication which effect mutagenic events. The area of DNA replication is rapidly advancing with increasing definition of the proteins required for initiation and elongation. At the same time, studies in mutagenesis are becoming defined at the molecular level with accumulation of a large mass of data with regard to the spectra of mutagenesis and the contributions of the host cell to mutagenesis. Recent evidence from several laboratories implicates specific replication events in mutagenesis and recently developed techniques allow the analysis of large numbers of transfecting or chromosomal mutations. It is the intent of this meeting to open new contacts between investigators. This meeting is not part of a continuing series, but has been designed to satisfy a defined need. We anticipate that the meeting will be attended by 200-250 outstanding individuals from around the world. Poster sessions will provide an opportunity for all investigators to present recent work in great detail. Discussion leaders and speakers will be drawn from outstanding members of the research community, but a distinct effort will be made to include junior investigators and those with recent striking findings in the formal presentations. Session chairman will be such outstanding scientists as Arthur Kornberg (Stanford), Charles Richardson (Harvard Med. School), Thomas Lindahl (ICRF, London), Paul Modrich (Duke U. Med. School), Harrison Echols (Berkeley), Jeffrey Miller (UCLA), and Peter Herrlich (Karlsruhe). The sessions will cover: the basic enzymology of DNA replication, including the components of the replicative apparatus; DNA replication systems, including both prokaryotic and eukaryotic studies; mechanisms of misincorporation, including errors by the synthesis apparatus as well as adduct formation; the genetic control of mutagenesis, with particular attention to mismatch repair; DNA polymerase functions in mutagenesis; damage-directed mutagenesis, with attention to the spectrum seen in transfecting and chromosomal genes; and induced mutagenesis, with updating on eukaryotic systems. The impact of this meeting should have long term affects on the research in the areas of DNA replication and damage, DNA repair, mutagenesis and cellular regulation of gene expression.

这次会议将汇集DNA领域的工作者， 复制和诱变的联合会议， 影响诱变事件的DNA复制事件。 DNA复制领域正在迅速发展， 增加起始所需蛋白质的定义 和伸长率。 与此同时， 在分子水平上， 大量关于诱变谱的数据 以及宿主细胞对诱变的贡献。 最近 几个实验室的证据表明 诱变中的复制事件， 技术允许分析大量的 或染色体突变。 本次会议的目的是 在调查人员之间建立新的联系。 这次会议不是 一个持续的系列的一部分，但已被设计为满足 定义的需要。 我们预计将有 来自世界各地的200 - 250名杰出人士。 海报会议将为所有人提供机会 调查人员详细介绍了最近的工作。 讨论领导人和发言人将从杰出的 研究界的成员，但一个独特的努力将 包括初级调查员和那些最近 在正式报告中有惊人的发现。 届会议 主席将是像亚瑟科恩伯格这样杰出的科学家 （斯坦福大学）、查尔斯·理查森（哈佛医学院）、托马斯 林达尔（ICRF，伦敦），保罗莫德里奇（杜克大学）。医学院）， 哈里森·埃科尔斯（伯克利），杰弗里米勒（加州大学洛杉矶分校）和彼得 Herrlich（Karlsruhe）. 会议将涵盖：基本的 DNA复制的酶学，包括 复制器; DNA复制系统，包括 原核和真核研究; 错误掺入，包括合成装置的错误 以及加合物的形成; 诱变，特别注意错配修复; DNA 聚合酶在诱变中的作用;损伤导向 诱变，注意在 诱变和染色体基因;以及诱导诱变， 更新真核生物系统 这样做的影响 会议应该对研究产生长期影响， DNA复制和损伤，DNA修复，诱变 和基因表达的细胞调节。