ASM Conference on DNA Replication and Mutagenesis, November 12-18, l987, Marco Island, FL

这次会议将把DNA复制和突变领域的工作人员聚集在一起，举行一次联合会议，重点讨论影响突变事件的DNA复制事件。随着对启动和延伸所需蛋白质的清晰度的提高，DNA复制的区域正在迅速推进。与此同时，随着关于诱变光谱和宿主细胞对诱变的贡献的大量数据的积累，对诱变的研究正变得在分子水平上进行。来自几个实验室的最新证据表明，突变中存在特定的复制事件，最近发展的技术使分析大量的转基因或染色体突变成为可能。这次会议的目的是在调查人员之间开启新的联系。这次会议不是连续系列会议的一部分，而是为满足明确的需求而设计的。我们预计将有来自世界各地的200-250名杰出人士参加会议。海报会议将为所有调查人员提供一个机会，详细介绍最近的工作。讨论领导人和发言者将从研究界的杰出成员中挑选出来，但将做出不同的努力，将初级调查人员和那些最近在正式陈述中有惊人发现的人包括在内。会议主席将由亚瑟·科恩伯格(斯坦福大学)、查尔斯·理查森(哈佛大学医学院)等杰出科学家担任。学校)，托马斯·林达尔(ICRF，伦敦)，保罗·莫德里奇(杜克大学医学院)。哈里森·埃科尔斯(伯克利)、杰弗里·米勒(加州大学洛杉矶分校)和彼得·赫利希(卡尔斯鲁厄)。这些会议将涉及：DNA复制的基本酶学，包括复制装置的组成部分；DNA复制系统，包括原核和真核研究；误结合的机制，包括合成装置的错误以及加合物的形成；突变的遗传控制，特别注意错配修复；DNA聚合酶在突变中的作用；损伤导向突变，注意在转基因和染色体基因中看到的光谱；以及诱导突变，更新真核系统。这次会议的影响应该会对DNA复制和损伤、DNA修复、突变和基因表达的细胞调控等领域的研究产生长期影响。

This meeting will bring together workers in the areas of DNA replication and mutagenesis for a combined meeting focusing on the events of DNA replication which effect mutagenic events. The area of DNA replication is rapidly advancing with increasing definition of the proteins required for initiation and elongation. At the same time, studies in mutagenesis are becoming defined at the molecular level with accumulation of a large mass of data with regard to the spectra of mutagenesis and the contributions of the host cell to mutagenesis. Recent evidence from several laboratories implicates specific replication events in mutagenesis and recently developed techniques allow the analysis of large numbers of transfecting or chromosomal mutations. It is the intent of this meeting to open new contacts between investigators. This meeting is not part of a continuing series, but has been designed to satisfy a defined need. We anticipate that the meeting will be attended by 200-250 outstanding individuals from around the world. Poster sessions will provide an opportunity for all investigators to present recent work in great detail. Discussion leaders and speakers will be drawn from outstanding members of the research community, but a distinct effort will be made to include junior investigators and those with recent striking findings in the formal presentations. Session chairman will be such outstanding scientists as Arthur Kornberg (Stanford), Charles Richardson (Harvard Med. School), Thomas Lindahl (ICRF, London), Paul Modrich (Duke U. Med. School), Harrison Echols (Berkeley), Jeffrey Miller (UCLA), and Peter Herrlich (Karlsruhe). The sessions will cover: the basic enzymology of DNA replication, including the components of the replicative apparatus; DNA replication systems, including both prokaryotic and eukaryotic studies; mechanisms of misincorporation, including errors by the synthesis apparatus as well as adduct formation; the genetic control of mutagenesis, with particular attention to mismatch repair; DNA polymerase functions in mutagenesis; damage-directed mutagenesis, with attention to the spectrum seen in transfecting and chromosomal genes; and induced mutagenesis, with updating on eukaryotic systems. The impact of this meeting should have long term affects on the research in the areas of DNA replication and damage, DNA repair, mutagenesis and cellular regulation of gene expression.