Extracting energy from air: mechanism of a bacterial hydrogenase

从空气中提取能量：细菌氢化酶的机制

• 批准号: DP230103080
• 负责人: Prof Chris Greening
• 金额: $ 49.2万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2023
• 资助国家: 澳大利亚
• 起止时间: 2023-01-01 至 2025-12-31
• 项目状态: 未结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP230103080
• 关键词: Extracting; energy; air; mechanism; bacterial

The atmosphere has recently been shown to be a key source of energy for diverse soil bacteria. Bacteria use complex enzymes, namely Huc-type hydrogenases, to harvest atmospheric hydrogen directly from air to support growth and survival. However, little is known about how Huc functions within and outside cells. By synergising expertise in microbiology, biochemistry, and chemistry, we will resolve the mechanism, assembly, and integration of Huc, including the basis of its remarkably high affinity and oxygen insensitivity compared to previously studied hydrogenases. This project will enable biotechnological applications, as the first study of an enzyme that extracts energy from air, and has broad ecological and biogeochemical implications.

最近的研究表明，大气是各种土壤细菌的主要能量来源。细菌使用复杂的酶，即Huc-type氢化酶，直接从空气中收获大气氢，以支持生长和生存。然而，人们对Huc在细胞内外的功能知之甚少。通过协同微生物学，生物化学和化学方面的专业知识，我们将解决Huc的机制，组装和整合，包括与以前研究的氢化酶相比，其显着高亲和力和氧不敏感性的基础。该项目将使生物技术应用成为可能，作为对从空气中提取能量的酶的首次研究，并具有广泛的生态和地球化学影响。