Purchase of a High Mass High Performance Tandem Mass Spectrometer

购买高质量高性能串联质谱仪

• 批准号: 8804502
• 负责人: Daniel Knapp
• 金额: $ 50万
• 依托单位: Medical University of South Carolina
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 1988
• 资助国家: 美国
• 起止时间: 1988-11-15 至 1991-04-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=8804502&HistoricalAwards=false
• 关键词: Purchase; Mass; Performance; Tandem; Spectrometer

This award will provide partial funding for the purchase of a high mass, high performance tandem mass spectrometer. The machine will be used for determination of amino acid sequences, characterization of post-transcriptional modifications of proteins and structural characterization of cross-linked ligand-receptor complexes, synthetic polypeptides and other compounds of biological interest. Among the proteins to be examined are membrane-bound receptors, hormones, enzymes and transcription factors. The remaining funds neccessary for purchase of the instrument will be provided by the university. Mass spectrometry is a technique of increasing utility in the structural characterization of a wide variety of biochemical compounds. Of particular interest is the use of this technique in the sequence analysis of modified proteins, peptidoglycans and other polysaccharides, since this information is often difficult or impossible to obtain by other means. The planned uses for this instrument should result in improved analytical methods as well as providing important new information about particular molecules.

该奖项将为购买高质量、高性能串联质谱仪提供部分资金。 该机器将用于测定氨基酸序列、蛋白质转录后修饰的表征以及交联配体-受体复合物、合成多肽和其他具有生物学意义的化合物的结构表征。 待检查的蛋白质包括膜结合受体、激素、酶和转录因子。 购买仪器所需的剩余资金将由大学提供。 质谱分析是一种在多种生化化合物的结构表征中越来越实用的技术。 特别令人感兴趣的是该技术在修饰蛋白质、肽聚糖和其他多糖的序列分析中的使用，因为该信息通常很难或不可能通过其他方式获得。 该仪器的计划用途应该会改进分析方法，并提供有关特定分子的重要新信息。