Research Initiation: Fundamental Studies of Receptor- Mediated Cell Adhesion Using Two Simple Adhesion Assays

研究启动奖： 受体介导细胞的基础研究 使用两种简单粘附试验的粘附性 摘要 这一建议的重点是使用理论和 实验，以进一步我们对细胞的定量知识 粘连 这将通过深入研究两个 细胞粘附试验：粘附的平行板试验 在流动条件下，和离心测定。 前者是 这是一项重要的试验，它表明了控制 在脉管系统中发现的一种血管炎，在许多 生物技术设备;后者是一种诊断检测方法， 生物科学家来定量的，但谁的 解释和适当执行， 演示。 这里提出的系统研究应该产生重要的成果。 结果和测试假设关于细胞如何使粘合剂 联系人. 它应该为科学家提供有价值的信息 工程师们的目标是操纵细胞行为， 疾病状态，或设计和实施生物技术 涉及粘合剂相互作用的装置。

RESEARCH INITIATION AWARD: FUNDAMENTAL STUDIES OF RECEPTOR-MEDIATED CELL ADHESION USING TWO SIMPLE ADHESION ASSAYS ABSTRACT The focus of this proposal is to use a combination of theory and experiment to further our quantitative knowledge about cell adhesion. This is to be done through an intensive study of two assays for cell adhesiveness: a parallel plate assay for adhesion under conditions of flow, and a centrifugal assay. The former is an important assay which indicates the factors which control the type of adhesiveness found in the vasculature, and in many biotechnological devices; the latter is a diagnostic assay used by biological scientists to quantitate adhesiveness, but whose interpretation and proper implementation have yet to be demonstrated. The systematic studies proposed here should yield important results and test hypotheses about how cells make adhesive contacts. It should provide valuable information for scientists and engineers whose aims are to manipulate cell behavior in disease states, or to design and implement biotechnological devices which involve adhesive interactions.