Presidential Young Investigators Award

细胞行为受细胞表面受体的强烈影响 大分子 理论和实验都将用于 研究受体在几种重要生物学中的作用 过程包括细胞粘附、病毒感染、囊泡 融合和膜信号转导。 此类信息 将允许使用受体结合配体来操纵 生物反应器中的细胞行为，并开发治疗方法 异常的生物过程 感兴趣的一个领域是 受体介导的细胞粘附到配体包被的表面， 在细胞分离技术和生理学上 如癌细胞转移的过程。 明确定义 含有受体的细胞外基质样支持物， 将开发结合配体。 利用这些支持， 流动条件下白细胞的动态粘附， 的长期粘附、伸长和生理学， 基因工程细胞将被探索。 在这些 问题，实验分析使用数学模型 其采用真实的基本参数。 生物技术为未来带来了巨大的希望。 为了 设计细胞行为， 此外，有必要了解细胞行为， 的根本基础。 例如，诱导合成 来自细胞的高价值药物，或治疗 由于故障细胞，有必要有 关于细胞如何工作的详细信息。 分子对 细胞表面的受体在 向细胞传递信息。 建议研究 如何利用细胞受体来操纵和修饰 细胞行为 使用数学建模和 实验技术，定量关系之间 受体和细胞行为在几个重要的过程 例如细胞与表面的粘附， 病毒进入细胞，蛋白质的分泌将 研究了 这种理解可以用来开发 用于制药生产的生物反应器，治疗粘连- 相关疾病，如癌细胞通过 身体，分离细胞更有效，或阻止 病毒传播疾病的进展，如艾滋病。

Cell behavior is strongly influenced by cell surface receptor macromolecules. Both theory and experiment will be used to study the role of receptors in several important biological processes including cell adhesion, viral infection, vesicle fusion and membrane signal transduction. Such information will allow the use of receptor-binding ligands to manipulate cell behavior in bioreactors, and develop therapies for aberrant biological processes. One area of interest is receptor-mediated cell adhesion to ligand-coated surfaces, found in cell separation technology, and in physiological precesses such as cancer cell metastasis. Well-defined extracellular matrix-like supports which contain receptor- binding ligands will be developed. Using these supports both the dynamic adhesion of leukocytes under flow conditions and the long-term adhesion, elongation and physiology of genetically engineered cells will be explored. In these problems, experiments are analyzed using mathematical models which employ, real fundamental parameters. Biotechnology holds immense promise for the future. In order to engineer cellular behavior for commercial and societal gain, it is necessary to understand cellular behavior on a fundamental basis. For example, to elicit the synthesis of high value pharmaceuticals from cells, or treat diseases which result from malfunctioning cells, it is necessary to have detailed information about how the cell works. Molecules on the cell surface called receptors are extremely important in tranducing information to the cell. It is proposed to study how to exploit cell receptors to manipulate and modify cellular behavior. Using both mathematical modelling and experimental techniques, the quantitative relationship between receptors and cell behavior in several important processes such as the adhesion of cells to surfaces, the adhesion of viruses to cells, and the secretion of proteins will be studied. This understanding can then be used to develop bioreactors for pharmaceutical production, treat adhesion- related diseases such as the spread of cancer cells through the body, separate cells more efficiently, or block the progression of virally transmitted diseases, such as AIDS.