Desorption Ionization Studies Using Fourier Transform Mass Spectrometry

使用傅里叶变换质谱法进行解吸电离研究

• 批准号: 8821780
• 负责人: David Russell
• 金额: $ 24.65万
• 依托单位: Texas A&M Research Foundation
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 1989
• 资助国家: 美国
• 起止时间: 1989-03-15 至 1992-02-29
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=8821780&HistoricalAwards=false
• 关键词: Desorption; Ionization; Studies; Using; Fourier

This project is in the general area of analytical and surface chemistry and in the subfields of gas phase reactions and mass spectrometry. The focus of this research is to develop methods for structural characterization of large biomolecules and to study the fundamentals of ion trapping and ion detection using Fourier transform ion cyclotron resonance (FT-ICR). A large emphasis of this project will be placed on understanding dissociation reactions of peptides after photodissociation or reaction with organo-alkali metal ions. Specific studies are proposed to examine the factors which influence the ICR signal of various species which are analyzed using FT-ICR. This research is designed to better understand how large biomolecules will break apart in the gas phase after absortion of relatively high energy photons or reactions with alkali metal ion species. The ultimate goal of this research is to provide better capabilities for characterization of high molecular weight biomolecules.

这个项目属于分析化学和表面化学的一般领域，以及气相反应和质谱的子领域。本研究的重点是发展大型生物分子的结构表征方法，并研究利用傅里叶变换离子回旋共振（FT-ICR）进行离子捕获和离子检测的基本原理。这个项目的重点将放在理解多肽在光解离或与有机碱金属离子反应后的解离反应上。提出了具体的研究，以探讨影响各种物种的ICR信号的因素，并利用FT-ICR进行分析。这项研究旨在更好地了解大型生物分子在吸收相对高能光子或与碱金属离子发生反应后如何在气相中分解。本研究的最终目的是为高分子量生物分子的表征提供更好的能力。