Acquisition of a Cryoprobe for a NMR Spectrometer

获取用于核磁共振波谱仪的冷冻探针

• 批准号: 0840464
• 负责人: David Russell
• 金额: $ 24.72万
• 依托单位: Texas A&M University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-08-01 至 2013-07-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0840464&HistoricalAwards=false
• 关键词: Acquisition; Cryoprobe; NMR; Spectrometer

This award is funded under the American Recovery and Reinvestment Act of 2009 (Public Law 111-5). With support from the Chemistry Research Instrumentation and Facilities: Multiuser program (CRIF:MU), the Chemistry Department at Texas A&M University Main Campus will acquire a cryoprobe for a 500 MHz nuclear magnetic resonance (NMR) spectrometer. The increased sensitivity provided by this acquisition will advance a variety of research projects, including: 1) Analysis of natural product molecules from aquatic organisms, obtained only in small amounts; 2) Investigations of reaction mechanisms by quantitative NMR spectroscopy, requiring a high signal-to-noise ratio even of dilute samples, to achieve the necessary precision; 3) Studies of small amounts of unstable organometallic compounds and catalytic transition states; and 4) Investigations of enzyme-bound intermediates and membrane transport experiments employing isotopically enriched protein samples. NMR spectroscopy is a very powerful analytical technique for the analysis of materials in chemistry, biochemistry and biology research. The spectra enable researchers to identify and characterize their substances including transient intermediates from reactions. They provide information on the arrangement and connectivity of atoms in molecules and materials, i.e., their structures by detecting transitions between energy levels arising from the nuclear spin properties of atoms. The cryoprobe will have a significant impact on education both intra- and extramurally. At Texas A&M, graduate and undergraduate research students will benefit from the ability to obtain data from state-of-the-art instrumentation. In addition, to enhance regional impact, the instrument will be cyber enabled. Off campus users will be able to send their samples, and will have the choice of having spectra obtained by staff, or of performing the experiments themselves by remote control of the spectrometer. Faculty at the University of Texas-Pan American, Texas A&M University Corpus Christi, Texas A&M University Kingsville, Tarleton State University, and the University of Texas of the Permian Basin will have access to the spectrometer. Many of these institutions have high Hispanic enrollments making this acquisition available to significant numbers of underrepresented students.

该奖项是根据2009年《美国复苏和再投资法案》(公法111-5)提供资金的。在化学研究仪器和设施：多用户计划(CRIF：MU)的支持下，德克萨斯农工大学主校区的化学系将为500 MHz核磁共振(核磁共振)光谱仪购买一个低温探头。这项收购提供的更高的灵敏度将推动各种研究项目，包括：1)分析只能少量获得的水生生物的天然产品分子；2)通过定量核磁共振光谱研究反应机理，即使是稀释的样品也需要高信噪比，以达到必要的精度；3)研究少量不稳定的有机金属化合物和催化过渡态；以及4)利用同位素浓缩的蛋白质样品研究酶结合的中间体和膜传输实验。核磁共振波谱是一种非常强大的分析技术，可用于化学、生物化学和生物研究中的材料分析。这些光谱使研究人员能够识别和表征他们的物质，包括反应产生的瞬时中间体。它们提供了关于分子和材料中原子的排列和连通性的信息，即通过检测原子的核自旋性质引起的能级之间的跃迁来了解它们的结构。冰冻探头将对教育产生重大影响，无论是在体内还是在体外。在德克萨斯农工大学，研究生和本科生将受益于从最先进的仪器设备获取数据的能力。此外，为了加强区域影响，该工具将启用网络。校外用户可以发送他们的样品，并可以选择由工作人员获取光谱，或者通过远程控制光谱仪自己进行实验。德克萨斯大学泛美分校、德克萨斯农工大学科珀斯克里斯蒂分校、德克萨斯农工大学金斯维尔分校、塔尔顿州立大学和德克萨斯大学二叠纪盆地分校的教职员工将可以使用这台光谱仪。这些机构中的许多都有很高的西班牙裔入学人数，这使得相当数量的代表不足的学生可以获得这项收购。