Evaluation of the Novel Ether Lipids of Archaebacteria for Use in Ultrathin Membrane Technologies: Research Initiation Award

用于超薄膜技术的古细菌新型醚脂的评估：研究启动奖

• 批准号: 8910103
• 负责人: Harold Monbouquette
• 金额: $ 7万
• 依托单位: University of California-Los Angeles
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 1989
• 资助国家: 美国
• 起止时间: 1989-08-01 至 1992-07-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=8910103&HistoricalAwards=false
• 关键词: Evaluation; Novel; Ether; Lipids; Archaebacteria

Planar and vesicular membranes formed by archaebacteria ether lipids will be characterized and assessed as potential biomimetic membranes. Archaebacteria are a recently discovered life-form living in extreme environments including pH values less than 2.0 or greater than 9.0 in saturated salt solutions at temperatures greater than the normal boiling point of water. Polar lipids isolated from plasma membranes of the archaebacteria contain an ether linkage, rather than the ester linkages usually found in membrane lipids. Ester linkages are less susceptible to oxidation and hydrolysis; thus, more stable membrane mimetics can be constructed from them. Since the ether lipids contain polar groups like those in normal cell membranes, but are more stable than normal cell lipids, they seem to be ideal candidates for constructing synthetic analogues of cell membranes. The project will attempt: (1) to construct ultra thin separation membranes with outstanding selectivity and fluxes and (2) to make electrode coating to immobilize enzymes that catalyze hydroxylation of lipophiles.

古细菌醚脂形成的平面和泡状膜 将被表征和评估为潜在的仿生膜。 古细菌是最近发现的一种生活在极端环境中的生命形式， pH值小于2.0或大于9.0的环境中， 温度高于正常温度的饱和盐溶液 水的沸点。 从质膜分离的极性脂质 的古细菌含有醚键，而不是酯键。 通常在膜脂中发现的连接。 酯键较少 易于氧化和水解;因此，更稳定的膜 可以由它们构建模拟物。 由于醚脂中含有与正常细胞中相同的极性基团， 膜，但比正常细胞脂质更稳定，它们似乎 是构建细胞的合成类似物的理想候选者， 膜。 该项目将尝试：（1）构建超薄 具有突出的选择性和通量的分离膜和（2） 来制作电极涂层， 亲脂体的羟基化。