Displacement Chromatography on Cyclodextrin Silicas

这项研究是在分析和表面化学的一般领域和色谱的子领域。人们将开发方法，分离目前很难用现有方法纯化的被称为对映体的化合物。本研究的目的是通过开发环糊精修饰的二氧化硅，建立用于位移色谱分离对映体化合物的制备方法。这将解决制备纯手性化合物的重要制药问题，这些化合物有望用作抗炎、受体阻滞剂、血小板活化因子和抗溃疡药物。

This research is in the general area of analytical and surface chemistry and in the subfield of chromatography. Methods will be developed that permit the separation of compounds called enantiomers that are presently very difficult to purify by existing procedures. The objectives of this research are to establish preparative methods for separating enantiomeric compounds by developing cyclodextrin modified silicas for use in displacement chromatographic procedures. This would solve important pharmaceutical problems in the preparation of pure chiral compounds that hold promise for use as anti-inflammatory, beta-blocker, platelet activating factor and anti-ulcer drugs.