US-UK Cooperative Research: Cycloadditions for HeterocyclicSynthesis

该奖项将支持在杂环化合物领域的合作研究 埃默里大学的阿尔伯特·帕德瓦博士和 克里斯托弗·穆迪，英国伦敦帝国理工学院。 该项目的目标是制定一个普遍的， 一种合成新型杂环化合物的方法， 系统. 重点将放在使用1，3-偶极环加成 化学用于构建各种有趣的 杂环 在待研究的反应中有环加成反应。 羰基叶立德、氮杂叶立德和硫羰基叶立德的离子 叶立德 该项目将集中在使用铑催化 重氮羰基化合物的反应作为生成 各种1，3-偶极子。该项目将受益于 这是两名调查员的互补专长。领域 拟议的研究在制药业中至关重要。 工业，以及农业和摄影领域 化学品 这两位研究人员的共同努力很可能 为上述领域做出重要贡献。

This award will support collaborative research in heterocyclic chemistry between Dr. Albert Padwa, Emory University, and Dr. Christopher Moody, Imperial College of Science, London, England. The objective of the project is the development of a general, broadly applicable method for the synthesis of novel heterocyclic systems. Emphasis will be placed on the use of a 1,3-dipolar cycloaddition chemistry for the construction of a variety of interesting heterocycles. Among the reactions to be studies are cycloaddi- tions of carbonyl ylides, azomthine ylides and thicarbonyl ylides. The project will focus on using the rhodium catalyzed reaction of diazo carbonyl compounds as a method for generating a variety of 1,3-dipoles. The project will benefit from the complementary expertise of the two investigators. The area of proposed research is of paramount importance in the pharmaceutical industry, as well as in the areas of agricultural and photographic chemicals. The joint effort of these two researchers is likely to make a fundamental contribution to the above fields.