Application of Cascade Processes for the Synthesis of Polycyclic Ring Systems

这项研究的重点有两个方面。首先，Padwa教授将使用过渡金属催化的α -重氮羰基化合物的化学反应进行串联环。在第二部分的工作中，串联Pummerer Diels Alder反应一系列的-苯基亚砜甲基- α， β -不饱和酮将用于多环环的合成。有了这个奖项，合成有机项目支持了埃默里大学化学系的阿尔伯特·帕德瓦博士的研究。Padwa教授将把他的工作重点放在开发构建不寻常多环系统的新方法上。该方法将为制备包括生物碱在内的一系列有趣的靶分子提供一个总体框架。

The focus of this research is two-fold. First, professor Padwa will use transition-metal catalyzed chemistry of alpha-diazo carbonyl compounds for tandem annulations. In the second part of the work, the tandem Pummerer Diels Alder reaction of a series of beta-phenylsulfinylmethyl-alpha, beta-unsaturated ketones will be used for polycyclic ring synthesis.With this award, the Synthetic Organic Program is supporting the research of Dr. Albert Padwa of the Department of Chemistry at Emory University. Professor Padwa will focus his work on developing new methods for the construction of unusual polycyclic ring systems. This methodology will give a general framework for the preparation of a series of interesting target molecules which includes alkaloids.