Application of Cascade Processes for the Synthesis of Polycyclic Ring Systems

这项研究的重点是双重的。首先，帕德瓦教授将使用过渡金属催化的α-重氮羰基化合物的化学进行串联环化。在这项工作的第二部分，一系列β-苯亚磺甲基-α，β-不饱和酮的串联Pummerer Diels Alder反应将用于多环合成。有了这个奖项，合成有机计划将支持埃默里大学化学系的阿尔伯特·帕德瓦博士的研究。帕德瓦教授将把工作重点放在开发构建不寻常的多环环系统的新方法上。这一方法将为包括生物碱在内的一系列有趣的目标分子的制备提供一个总体框架。

The focus of this research is two-fold. First, professor Padwa will use transition-metal catalyzed chemistry of alpha-diazo carbonyl compounds for tandem annulations. In the second part of the work, the tandem Pummerer Diels Alder reaction of a series of beta-phenylsulfinylmethyl-alpha, beta-unsaturated ketones will be used for polycyclic ring synthesis.With this award, the Synthetic Organic Program is supporting the research of Dr. Albert Padwa of the Department of Chemistry at Emory University. Professor Padwa will focus his work on developing new methods for the construction of unusual polycyclic ring systems. This methodology will give a general framework for the preparation of a series of interesting target molecules which includes alkaloids.