Intramolecular Cyclization Reactions of Alkynyl Substituted Diazoketones

炔基取代的重氮酮的分子内环化反应

• 批准号: 9117088
• 负责人: Albert Padwa
• 金额: $ 30.4万
• 依托单位: Emory University
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 1992
• 资助国家: 美国
• 起止时间: 1992-01-01 至 1995-06-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9117088&HistoricalAwards=false
• 关键词: Intramolecular; Cyclization; Reactions; Alkynyl; Substituted

The focus of this research is the formation of polycyclic ring systems by the interaction of alpha-diazo alkynyl substituted ketones with various transition metals. The initially formed ketocarbenoid intermediate is projected to undergo an intramolecular addition to the acetylenic pi-bond to produce a vinylcarbenoid intermediate. The latter will be probed to study the potential for insertion into C-H bonds, addition to pi-bonds, 1,2-hydrogen and alkyl group migration and electrocyclization. %%% With this award, the Synthetic Organic Program is supporting the research of Dr. Albert Padwa of the Department of Chemistry at Emory University. Professor Padwa will focus his work on the development of new synthetic methods for the production of carbenoid intermediates and, thus, the preparation of unusual polycyclic ring systems.

本研究的重点是多环的形成 通过α-重氮炔基取代的 与各种过渡金属的酮。 最初形成的 酮基卡宾中间体预计将经历 分子内加成到炔属π键上， 乙烯基类卡宾中间体。 后者将被探讨 研究插入C-H键的可能性，此外， π键、1，2-氢和烷基迁移， 电环化 %%% 有了这个奖项，合成有机计划正在支持 化学系的阿尔伯特·帕德瓦博士的研究 在埃默里大学。 Padwa教授将把他的工作重点放在 开发新的合成方法生产 类卡宾中间体，因此，制备不寻常的 多环系统