Intramolecular Cyclization Reactions of Alkynyl Substituted Diazoketones

本研究的重点是α -重氮炔基取代酮与各种过渡金属相互作用形成多环体系。将最初形成的类酮中间体投射到乙炔键上进行分子内加成以生成乙烯基类碳中间体。后者将被研究插入C-H键、加入pi键、1,2-氢和烷基迁移和电环化的潜力。有了这个奖，合成有机项目就支持了埃默里大学化学系的阿尔伯特·帕德瓦博士的研究。Padwa教授将专注于开发新的合成方法，以生产类碳化合物中间体，从而制备不寻常的多环体系。

The focus of this research is the formation of polycyclic ring systems by the interaction of alpha-diazo alkynyl substituted ketones with various transition metals. The initially formed ketocarbenoid intermediate is projected to undergo an intramolecular addition to the acetylenic pi-bond to produce a vinylcarbenoid intermediate. The latter will be probed to study the potential for insertion into C-H bonds, addition to pi-bonds, 1,2-hydrogen and alkyl group migration and electrocyclization. %%% With this award, the Synthetic Organic Program is supporting the research of Dr. Albert Padwa of the Department of Chemistry at Emory University. Professor Padwa will focus his work on the development of new synthetic methods for the production of carbenoid intermediates and, thus, the preparation of unusual polycyclic ring systems.