Application of Cascade Processes for the Synthesis of Polycyclic Ring Systems

这项研究的重点是开发同时产生几个C-C键的串联反应序列。串联式Pummerer/Diels-Alder，2-氨基呋喃环加成反应，以及Venylogous和串联式Pummerer过程将作为复杂多环环系统的入口来研究。通过这一续展奖项，有机和高分子化学项目支持埃默里大学化学系的阿尔伯特·帕德瓦博士的研究。帕德瓦教授将把他的工作重点放在串联级联反应的开发上，以制备不寻常的多环环体系。其目的是为理解各种级联过程的重要因素和将反应序列应用于感兴趣的合成目标提供一个总体框架。

The focus of this research is the development of tandem reaction sequences for the simultaneous production of several C-C bonds. Tandem Pummerer/Diels-Alder, 2-aminofuran cycloadditions, and vinylogous and tandem Pummerer processes will be studied as entries into complex polycyclic ring systems. With this renewal award, the Organic and Macromolecular Chemistry Program is supporting the research of Dr. Albert Padwa of the Department of Chemistry at Emory University. Professor Padwa will focus his work on the develoment of tandem cascade reactions for the preparation of unusual polycyclic ring systems. The goal is to provide a general framework for understanding the important factors for various cascade processes and for applying the sequence of reactions to interesting synthetic targets.