Application of Cascade Processes for the Synthesis of Polycyclic Ring Systems

这项研究的重点有三个方面。 首先，使用铑卡宾的串联环化/环加成将用于制备天然产物，例如天然产物komaroviquinone。 第二，硫代异孟酮的环加成和环化反应将用于eburnamenine和aspidosperma家族的代表性生物碱的合成。 第三，使用各种肟和2，3-双（苯磺酰基）-1，3-二烯的多米诺环形成反应将导致形成含哌啶的化合物，如海洋生物碱halichlorine。通过这一更新奖项，有机和大分子化学计划支持埃默里大学化学系的Albert Padwa博士的研究和教育活动。 Padwa教授将专注于开发串联或级联方法，用于在一次操作中形成几个碳-碳键和/或环系统。 阳离子、阴离子、自由基、类卡宾或周环过程的组合将用于组装复杂的靶分子。 该项目的更广泛影响是在研究生培训领域，这项工作对制药业有重大影响。

The foci of this research are threefold. First, tandem cyclization/cycloaddition with rhodium carbenoids will be used to prepare natural products, for example the natural product komaroviquinone. Second, the cycloaddition and cyclization reactions of thioisomunchnones will be employed for alkaloid syntheses of representatives of the eburnamenine and aspidosperma families. Third, domino ring-forming reactions using various oximes and 2,3-bis(phenylsulfonyl)-1,3-diene will lead to the formation of piperidine-containing compounds such as halichlorine, a marine alkaloid.With this renewal award, the Organic and Macromolecular Chemistry Program is supporting the research and educational activities of Dr. Albert Padwa in the Department of Chemistry at Emory University. Professor Padwa will focus his work on developing tandem, or cascade, methods for the formation of several carbon-carbon bonds and/or ring systems in a single operation. A combination of cationic, anionic, radical, carbenoid or pericyclic processes will be used to assemble complex target molecules. Broader impacts of the project are in the area of training of graduate students and the work has significant implications for the pharmaceutical industry.