Acquisition of a Hybrid Mass Spectrometer

一个联合质谱设施已经建立， 环境科学与工程与化学系 在查佩尔山的北卡罗来纳州大学。 的 该基金的目标是支持和促进化学品 质谱研究和教学。 该设施 将提供识别和结构能力 许多不同种类的化合物的表征。 具体 主要用户的一些项目的目的是了解 进入负责激活多环 芳香族化合物的终极致癌物;了解固醇代谢 植物寄生物中的途径;合成非遗传蛋白质; 表征蜕皮甾类生物合成中的中间体 并鉴定控制昆虫的神经肽 发展;了解-羧基谷氨酰（Gla）的作用 血液凝固过程中的残留物;表征强效 酶抑制剂，并分离和鉴定 水中腐殖酸的氯化和电离。 为这些 因此，需要一种质谱仪，其能够高- 分辨率和精确的质量测量，化学电离， 碰撞激活电离，碰撞激活，气体- 色谱和快速原子轰击。 最合适的 仪器是混合质谱仪。

A joint Mass Spectrometry Facility has been created by the Department of Environmental Sciences and Engineering and Chemistry at the University of North Carolina at Chapel Hill (UNC). The objectives of the Facility are to support and promote chemical research and teaching in mass spectrometry at UNC. The Facility will provide the capability for identification and structural characterization of many different classes of compounds. Specific aims of some of the projects of the major users are to gain insight into mechanisms responsible for the activation of polycyclic aromatics to ultimate carcinogens; to understand sterol metabolic pathways in the plant parasites; to synthesize nongenetic proteins; to characterize intermediates in the biosynthesis of ecodysteroids in insects and to identify neuropeptides controlling insect development; to understand the role of -carboxyglutamyl (Gla) residues in blood coagulation processes; to characterize potent enzyme inhibitors and to separate and identify products of chlorination and ionization of humics in water. For these purposes, an mass spectrometer is needed that is capable of high- resolution and accurate mass measurements, chemical ionization, collisional activation ionization, collisional activation, gas- chromatography and fast-atom-bombardment. The most appropriate instrument is a hybrid-mass spectrometer.