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Hybrid-Mass-Spectrometer

混合质谱仪

基本信息

批准号：
438654181
负责人：
金额：
--
依托单位：
Ludwig-Maximilians-Universität München (LMU)
依托单位国家：
德国
项目类别：
Major Research Instrumentation
财政年份：
2020
资助国家：
德国
起止时间：
2019-12-31 至无数据
项目状态：
未结题

来源：
https://gepris.dfg.de/gepris/projekt/438654181?language=en
关键词：
Hybrid Mass Spectrometer

项目摘要

The Ice Dust Sequencing Laboratory (IDSL) is a central facility of the Origins Cluster. It is used for collaboration in the field of early molecular evolution. The aim is to provide complex methodologies for the analysis and synthesis of prebiotic molecules centrally and to make them available to the participating groups together with a technical staff (TA) position of the cluster. Different disciplines meet in this central lab facility: physics, chemistry, geosciences and biochemistry. The aim is to enable PhD students and postdocs from the Cluster and the CRC Emergence of Life to carry out measurements independently under the guidance of the TA. As shown in the Appendices 101, the eight participating groups describe the projects with which they can use the mass spectrometer. Due to the large number of projects, a good utilization of the mass spectrometer is garanteed. For the direct analysis of complex reaction mixtures in aqueous and polar reaction media, a highly efficient separation performance in combination with high-resolution mass spectrometer is required to clearly identify reaction products and intermediates. HPLC (already acquired via the Cluster and the CRC Emergence of Life) in combination with the applied Orbitrap mass spectrometer is central here. We will be able to combine the mass spectrometer with electrospray (Trapp group) and gas chromatography (Eisenreich group) in the future. This allows us to reliably elucidate complex reaction mixtures from Origins of Life experiments. In particular, we will be able to use the mass spectrometer to clarify unknown side products in complex reaction mixtures.

冰尘测序实验室（IDSL）是起源集群的中心设施。它用于早期分子进化领域的合作。其目的是为益生元分子的集中分析和合成提供复杂的方法，并使其与集群的技术人员（TA）位置一起提供给参与小组。不同的学科汇集在这个中心实验室设施：物理，化学，地球科学和生物化学。目的是使来自集群和CRC生命出现的博士生和博士后能够在TA的指导下独立进行测量。如附录101所示，八个参与小组描述了他们可以使用质谱仪的项目。由于项目数量多，保证了质谱仪的良好利用。对于水相和极性反应介质中复杂反应混合物的直接分析，需要高效的分离性能与高分辨率质谱仪相结合，清晰地识别反应产物和中间体。HPLC（已经通过Cluster和CRC的Emergence of Life获得）结合应用的Orbitrap质谱仪是这里的核心。在未来，我们将能够将质谱仪与电喷雾（Trapp group）和气相色谱（Eisenreich group）相结合。这使我们能够从生命起源实验中可靠地阐明复杂的反应混合物。特别是，我们将能够使用质谱仪来澄清复杂反应混合物中的未知副产物。