Gas Chromatography-Mass Spectrometry in Undergraduate Chemistry Instruction

气相色谱-质谱法在本科化学教学中的应用

• 批准号: 9051169
• 负责人: Bert Holmes
• 金额: $ 3.19万
• 依托单位: Lyon College
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 1990
• 资助国家: 美国
• 起止时间: 1990-04-01 至 1992-09-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9051169&HistoricalAwards=false
• 关键词: Gas; Chromatography; Mass; Spectrometry; Undergraduate

Through this project, the institution was able to purchase a gas chromatograph/mass spectrometer. A central theme is the improvement of students' understanding of reaction mechanisms and stereochemistry. In the first semester Organic Chemistry, GC/MS helped to introduce the concept of carbocation stability. In the second semester, GC/MS was used to analyze the stereochemistry of addition reactions that form threo- or erythro-bromo- deuteriobutane and the subsequent base-promoted elimination reactions of these stereoisomers. Such difficult concepts are seldom addressed in conventional organic laboratory due to the lack of proper instrumentation. In Physical Chemistry the GC/MS is being used to determine kinetic isotope effects and stereochemistry for gas-phase syn-elimination of the previously prepared deuterated bromobutanes. The Instrumental Chemistry course is emphasizing technique, operation of the instrument, its capabilities and interpretation of spectra. In Environmental Chemistry GC/MS is helping demonstrate detection and quantification of organic contaminants in ground water. Many students find the GC/MS vital to their undergraduate research projects. Through more sophisticated experiments the GC/MS is improving instruction in Organic, Physical, Instrumental, and Environmental Chemistry courses. The institution contributed to this project in an amount equal to the NSF funds.

通过这个项目，该机构能够购买一台气相色谱仪/质谱仪。一个中心主题是提高学生对反应机制和立体化学的理解。在第一学期的有机化学中，GC/MS帮助引入了碳正离子稳定性的概念。在第二学期，我们使用GC/MS分析了形成三溴或红溴-氘丁烷的加成反应的立体化学，以及随后这些立体异构体的碱促进消除反应。由于缺乏适当的仪器，这些困难的概念很少在传统的有机实验室中得到解决。在物理化学中，GC/MS被用于测定动力学同位素效应和气相消去氘化溴丁烷的立体化学。仪器化学课程强调技术、仪器的操作、仪器的能力和光谱的解释。在环境化学中，GC/MS正在帮助演示地下水中有机污染物的检测和定量。许多学生发现GC/MS对他们的本科研究项目至关重要。通过更复杂的实验，GC/MS正在改善有机化学、物理化学、仪器化学和环境化学课程的教学。该机构为该项目提供的资金相当于国家科学基金会的资金。