Mechanisms of Intestinal Nutrient Transport and Their Regulation in Fish

这项为期三年的调查是夏威夷大学和意大利莱卡大学之间的一项国际交流研究计划的延续，该计划旨在研究对两国具有重要经济意义的鱼类肠道营养物质运输的比较生理学。夏威夷和意大利目前都在进行广泛的水产养殖活动，以帮助满足人类对蛋白质日益增长的需求。鱼类经济发展面临的一个严重问题是生产一种营养丰富且价格低廉的人工饲料。这项先前非常成功的研究工作的扩展将使用几种体外实验室方法来阐明糖、氨基酸、肽和短链脂肪酸在两个实验室中从草食性和肉食性鱼类的肠道和相关憩室中运输的机制。从这些生理研究中获得的新信息可能对未来开发这些鱼类的人工饲料具有重要意义，并可能缩短每种鱼类充分发挥其水产养殖潜力所需的时间。

The proposed three year investigation is a request for a continuation of an international exchange research program between the University of Hawaii and the University of Lecca, Italy examining the comparative physiology of intestinal nutrient transport in fish of economic importance in both countries. Hawaii and Italy both have extensive fish aquacultural activities currently underway to help meet the burgeoning human need for protein. A serious problem to fish economic development is the production of an artificial diet that is nutritious and inexpensive. The requested extension of this previously highly successful research effort will use several in vitro laboratory methods to elucidate the mechanisms of sugar, amino acid, peptide, and short chain fatty acid transport in the intestines and associated diverticula from herbivorous and carnivorous fishes at the two laboratories. The novel information resulting from these physiological studies may be important in the future development of artificial diets for these respective fishes and may reduce the time necessary for each species to reach their full aquaculture potential.