Enhanced Fluidity Liquid Chromatographies

增强流动性液相色谱

• 批准号: 9118913
• 负责人: Susan Olesik
• 金额: --
• 依托单位: Ohio State University Research Foundation -DO NOT USE
• 依托单位国家: 美国
• 项目类别: Continuing grant
• 财政年份: 1992
• 资助国家: 美国
• 起止时间: 1992-02-01 至 1995-07-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9118913&HistoricalAwards=false
• 关键词: Enhanced; Fluidity; Liquid; Chromatographies

This project is in the general area of analytical and surface chemistry and in the subfield of separation science. During the tenure of this three-year continuing grant, Professor Olesik and her students will pursue fundamental investigations of the physicochemical properties of conventional liquid chromatography mobile phases that have been mixed with supercritical fluids, particularly supercritical carbon dioxide, to provide new mobile phases with enhanced fluidities and diffusivities. These new mobile phases will enable more rapid analysis by high performance liquid chromatography (HPLC) and size exclusion chromatography (SEC). %%% This research builds upon preliminary results and new theoretical developments from Dr. Olesik's laboratory. In addition to contributing to the fundamental basis of liquid chromatography, these studies are relevant to other technologically important areas such as solvent extraction and synthesis where enhanced fluidity reaction environments can give rise to more efficient chemical processes.

这个项目是在分析和表面化学的一般领域和分离科学的子领域。在这项为期三年的持续资助中，Olesik教授和她的学生将对传统液相色谱流动相的物理化学性质进行基础研究，这些流动相与超临界流体（特别是超临界二氧化碳）混合，以提供具有增强流动性和扩散率的新流动相。这些新的流动相将使高效液相色谱（HPLC）和粒径排除色谱（SEC）的分析更加快速。这项研究建立在奥列西克博士实验室的初步结果和新理论发展的基础上。除了为液相色谱的基本基础做出贡献外，这些研究还与其他技术上重要的领域相关，例如溶剂萃取和合成，其中增强的流动性反应环境可以产生更有效的化学过程。