Enhancing the Performance of High Performance Liquid Chromatography and Mass Spectrometry Using Nanofibers

本项目由国家科学基金会化学部化学测量与成像计划资助。俄亥俄州立大学的苏珊·奥莱西克教授正在开发能够检测低浓度化合物的分析方法，与目前的能力相比，分析时间有所改善。这项工作可能会影响该国日益增加的挑战，例如需要监测天然水中的低水平污染物，以及需要进行快速的临床和法医分析。这项工作的更广泛的影响包括碳基固定相的发现带来的潜在的社会效益，以及中学生和教师参与到这项研究产生的活跃的科学项目中。该项目侧重于具有更高的动力学性能、更高的灵敏度和独特的选择性的液相色谱-质谱学方法。有四个项目目标。首先，正在开发一种碳基开管液相色谱方法。第二，正在研究和开发碳基填充液相色谱柱。第三，研究了纳米纤维表面辅助激光解吸电离的机理。第四，开发了与中学学习兼容的基于纳米纤维的平面层析，并将其添加到针对当地中学的新的主动学习、科学推广计划中。

This project is funded by the Chemical Measurement & Imaging Program of the Chemistry Division at the National Science Foundation. Professor Susan Olesik of the Ohio State University is developing analysis methods with the ability to detect compounds at low concentration levels with improved analysis time compared to current capabilities. Increasing challenges in this country such as the need to monitor low levels of pollutants in natural waters and the need for fast clinical and forensic analyses may be impacted by this work. The broader impacts of this work include the potential societal benefits from the discoveries of the carbon based stationary phases as well as, middle school student and teacher engagement in active science projects developed from this research.This project focuses on liquid chromatography-mass spectrometric methods with increased kinetic performance, improved sensitivity, and unique selectivity. There are four project goals. First, a carbon based open tubular liquid chromatographic methods is being developed. Second, a carbon based packed liquid chromatographic column is being studied and developed. Third, the mechanism of nanofiber-based surface assisted laser desorption ionization are studied. Fourth, nanofiber based planar chromatography that is compatible with middle school studies are developed and added to a new active-learning, science outreach program for local middle schools.