Enhancing the Performance of High Performance Liquid Chromatography and Mass Spectrometry Using Nanofibers

该项目由美国国家科学基金会化学部的化学测量成像计划资助。俄亥俄州州立大学的Susan Olesik教授正在开发一种分析方法，该方法能够检测低浓度水平的化合物，与目前的能力相比，分析时间有所改善。这项工作可能会影响该国日益严峻的挑战，例如需要监测天然沃茨中的低水平污染物，以及需要快速进行临床和法医分析。这项工作的广泛影响包括碳基固定相的发现带来的潜在社会效益，以及中学生和教师参与这项研究开发的活跃科学项目。该项目重点关注具有更高动力学性能、更高灵敏度和独特选择性的液相色谱-质谱方法。项目有四个目标。首先，正在开发基于碳的开管液相色谱方法。第二，正在研究和开发碳基填充液相色谱柱。第三，研究了纳米纤维表面辅助激光解吸电离的机理。第四，开发了与中学学习兼容的基于手性的平面色谱，并将其添加到当地中学的新的主动学习科学推广计划中。

This project is funded by the Chemical Measurement & Imaging Program of the Chemistry Division at the National Science Foundation. Professor Susan Olesik of the Ohio State University is developing analysis methods with the ability to detect compounds at low concentration levels with improved analysis time compared to current capabilities. Increasing challenges in this country such as the need to monitor low levels of pollutants in natural waters and the need for fast clinical and forensic analyses may be impacted by this work. The broader impacts of this work include the potential societal benefits from the discoveries of the carbon based stationary phases as well as, middle school student and teacher engagement in active science projects developed from this research.This project focuses on liquid chromatography-mass spectrometric methods with increased kinetic performance, improved sensitivity, and unique selectivity. There are four project goals. First, a carbon based open tubular liquid chromatographic methods is being developed. Second, a carbon based packed liquid chromatographic column is being studied and developed. Third, the mechanism of nanofiber-based surface assisted laser desorption ionization are studied. Fourth, nanofiber based planar chromatography that is compatible with middle school studies are developed and added to a new active-learning, science outreach program for local middle schools.