Novel Carbon Media for Separation Science

俄亥俄州立大学苏珊·奥莱西克教授的项目由分析和表面化学计划支持，旨在开发能够分离结构差异最小的化合物的色谱介质。最近对玻碳保留机理的研究表明，玻碳能够通过不同的保留机制与极性和非极性分析物发生强烈的相互作用。因此，玻碳的层析应用得到了极大的扩展。此外，固体吸附剂通常是分离结构差异最小的化合物的非常好的候选者。由于聚合物前体和生产方法的原因，目前只有一种商业上可获得的用于分离化合物的玻璃炭材料，并且其限于多孔性颗粒的构型。新的前体聚合物，双乙炔聚合物，允许在最低温度下以最小的重量损失生产玻璃炭。这些前驱体聚合物也很容易溶于有机溶剂，从而可以生产连续的低温玻璃碳膜。此外，微晶尺寸和石墨化程度可以随薄膜处理温度的不同而变化。此外，低温玻碳(LTGC)表面可以包括共价键合的非碳原子。这样的组装层析介质在包括药物在内的大量化学物质的分离和纯化方面具有潜在的应用。这项工作将研究用精选双乙酰聚合物生产的低温玻碳的表面化学，并将开发基于表面化学的新的选择性层析介质。薄层色谱被认为是独特的，应该提供独特的色谱选择性和广泛的应用。纯碳LTGC、全氟化LTGC和含氮LTGC膜将被表征用于液相色谱。新构型的GC，特别是无孔LTGC颗粒，将与薄膜介质进行比较。

The project of Professor Susan Olesik of Ohio State University, supported by the Analytical and Surface Chemistry program, is to develop chromatographic media capable of separating compounds that differ minimally in their structure. Recent studies on the mechanisms of retention on glassy carbon (GC) have shown that glassy carbon is capable of interacting strongly with both polar and nonpolar analytes through different retention mechanisms. Accordingly the chromatographic applications of glassy carbon have expanded substantially. Also, solid adsorbents are typically very good candidates for the separation of compounds that differ minimally in structure. Due to the polymer precursor and the method of production, there is presently only one commercially-available glassy carbon material for the separation of compounds and it is limited to the configuration of porous particles. New precursor polymers, diacetylenic polymers, allow the production of glassy carbon at low temperatures with minimal weight loss. These precursor polymers are also readily soluble in organic solvents allowing the production of continuous low temperature glassy carbon films. In addition, the microcrystallite size and the extent of graphitization can be varied with film processing temperatures. Furthermore, low temperature glassy carbon (LTGC) surfaces can be made that include noncarbon atoms covalently bound in its structure.Fabricated chromatographic media such as these have potential applications to the separation and purification of a large number of chemicals, including pharmaceuticals. This work will study the surface chemistry of the low temperature glassy carbons (LTGC) produced using select diacetylenic polymers and will develop new selective chromatographic media based on the surface chemistry. LTGCs are expected to be distinctive and should provide unique chromatographic selectivity and extensive applications. Pure carbon LTGC, perfluorinated LTGC, and nitrogen-containing LTGC films will be characterized for use in liquid chromatography. New configurations of GC, specifically nonporous LTGC particles, will be compared to the thin film media.