Mechanistic Studies of Free Radical Additions and Rearrangements

自由基的立体化学控制研究 将进行添加过程。的总体目标 研究的目的是确定自由基加成的机理 导致精确控制立体化学的过程 产生的最终产品。待研究的反应 在这个项目的过程中，包括激进的补充， 原子转移和含酰胺烯烃的聚合 辅助设备.精确调节聚合物的立构规整度 特别设计的低聚物和聚合物将被 通过使用非常特定的立体化学反应来完成。 寡聚体的确切分布将通过以下方式调节： 胶束环境中的反应，旨在产生 离散的反应步骤数。此外，化学 过氧自由基重排和环化反应将 通过使用立体化学探针和氧来研究 同位素 %%% 有机动力学计划的这笔赠款支持 继续教授的工作。A.杜克大学的波特。 这些研究将集中在设计准确的 分子结构的高效和选择性 自由基反应通过强迫化学反应 放置在非常特定的途径中，有可能产生 这些分子被设计用来解决重要的问题， 由于其精心控制的结构。之一 这项工作的最终目标是使分子， 在空间中具有完全相同方向的重复单元。这 会导致分子具有非常不寻常的性质。

An investigation of stereochemical control of free radical addition processes will be conducted. The overall goal of the research is to define the mechanism of free radical addition processes which results in exact control of the stereochemistry of the final products generated. Reactions to be investigated during the course of this project include radical additions, atom transfer, and polymerizations of alkenes bearing amide auxiliaries. Precise regulation of the tacticity of specifically engineered oligomers and polymers will be accomplished by use of very specific stereochemical reactions. The exact distribution of oligomers will be regulated by reactions in micellar environments designed to produce a discrete number of reaction steps. In addition, the chemistry of peroxyl radical rearrangement and cyclization reactions will be investigated by the use of stereochemical probes and oxygen isotopes. %%% This grant from the Organic Dynamics Program supports the continuing work of Professor N. A. Porter at Duke University. The studies will center around efforts to engineer the exact structure of molecules by extremely efficient and selective free radical reactions. By forcing chemical reactions to take place in very specific pathways, it is possible to generate molecules that are designed to solve important problems by virtue of their carefully controlled structure. One of the final goals of this work is to make molecules which have many repeat units of exactly the same orientation in space. This will result in molecules with very unusual properties.