Mechanistic Studies of Free Radical Additions and Rearrangements

自由基加成和重排的机理研究

• 批准号: 9423572
• 负责人: Ned Porter
• 金额: $ 49.03万
• 依托单位: Duke University
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 1995
• 资助国家: 美国
• 起止时间: 1995-04-15 至 1998-03-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9423572&HistoricalAwards=false
• 关键词: Mechanistic; Studies; Free; Radical; Additions

With funding from the Organic Dynamics Program, Professor Porter of Duke University will explore the mechanisms of reactions involving organic free radicals. These rather transitory intermediates are having increasing impact on both the organic and the chemical community at large. More specifically, free radical induced polymerization of monomers is a major commercial pathway to useful products. Moreover, control of the chirality of these polymerization reactions at the evolving stereogenic centers represents a very significant advance. This proposal addresses these issues very creatively. Discovering means to control organic reactions so as to produce desirable and useful products in a significant goal to have major impact. This grant outlines an investigation which, if successful, will discover new ways of controlling the reaction of free radical polymerization monomeric subunits. Since these subunits are natural resources, this work prescribes a methodology whereby a significant improvement can be made in their use. This means an increase in the efficiency and a major saving of resources.

在有机动力学项目的资助下，杜克大学的波特教授将探索涉及有机自由基的反应机制。 这些相当短暂的中间体对整个有机和化学界的影响越来越大。 更具体地，单体的自由基诱导聚合是获得有用产品的主要商业途径。 此外，控制这些聚合反应的手性在不断发展的立体中心代表了一个非常显着的进步。 这项建议非常有创造性地处理了这些问题。 发现是指控制有机反应，使其产生所需的有用的产品，在一个有意义的目标中产生重大影响。 这项资助概述了一项研究，如果成功，将发现控制自由基聚合单体亚基反应的新方法。 由于这些亚单位是自然资源，这项工作规定了一种方法，从而可以在其使用中取得显着的改善。 这意味着效率的提高和资源的大量节省。