Peroxide Reaction Mechanisms

通过这一续展奖项，有机和高分子化学项目继续支持田纳西州纳什维尔范德比尔特大学化学系Ned A.Porter教授的工作。这项研究将扩大PI对化学和生化体系中氧化机理的研究。为了促进这些机理的研究，将开发一系列自由基时钟。这些时钟将被用来测量过氧基与各种生物相关底物的反应速度。这项技术将允许在很大范围内测量速率常数。取代吡啶醇是一种新的抗氧化剂，它与过氧化自由基的反应速度似乎比维生素E快10到100倍，我们将对其进行研究。各种这些吡啶醇将被评估为低密度脂蛋白中的抗氧化剂，低密度脂蛋白的过氧化已被认为与冠状动脉疾病的发展有关。这项研究将让学生参与一个广泛的跨学科项目，预计将提供基本数据，有助于我们对抗氧化剂化学和生物学的基本理解。

With this renewal award, the Organic and Macromolecular Chemistry Program continues its support of the work of Professor Ned A. Porter of the Department of Chemistry at Vanderbilt University in Nashville, TN. The research will extend the PI's investigations of the mechanism of oxidations in chemical and biochemical systems. In order to facilitate these mechanistic studies, a series of free radical clocks will be developed. These clocks will be used to measure the rates of reaction of peroxyl radicals with a variety of biologically relevant substrates. The technique will allow measurements over a wide range of rate constants. The chemistry of substituted pyridinols, a new class of antioxidants that appear to react with peroxyl radicals some 10 to 100 times faster than vitamin E, will be examined. A variety of these pyridinols will be evaluated as antioxidants in low-density lipoproteins, LDL, the peroxidation of which has been implicated the development of coronary artery disease. This research, which will involve students in a broadly interdisciplinary program, is expected to provide fundamental data that will contribute to our basic understanding of antioxidant chemistry and biology.