Peroxide Reaction Mechanisms

过氧化物反应机理

• 批准号: 0412493
• 负责人: Ned Porter
• 金额: $ 56.9万
• 依托单位: Vanderbilt University
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-09-01 至 2008-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0412493&HistoricalAwards=false
• 关键词: Peroxide; Reaction; Mechanisms

With this renewal award, the Organic and Macromolecular Chemistry Program continues its support of the work of Professor Ned A. Porter of the Department of Chemistry at Vanderbilt University in Nashville, TN. The research will extend the PI's investigations of the mechanism of oxidations in chemical and biochemical systems. In order to facilitate these mechanistic studies, a series of free radical clocks will be developed. These clocks will be used to measure the rates of reaction of peroxyl radicals with a variety of biologically relevant substrates. The technique will allow measurements over a wide range of rate constants. The chemistry of substituted pyridinols, a new class of antioxidants that appear to react with peroxyl radicals some 10 to 100 times faster than vitamin E, will be examined. A variety of these pyridinols will be evaluated as antioxidants in low-density lipoproteins, LDL, the peroxidation of which has been implicated the development of coronary artery disease. This research, which will involve students in a broadly interdisciplinary program, is expected to provide fundamental data that will contribute to our basic understanding of antioxidant chemistry and biology.

有了这个更新奖，有机和高分子化学计划继续支持教授内德A。位于田纳西州纳什维尔的范德比尔特大学化学系的波特说。 该研究将扩展PI对化学和生物化学系统中氧化机制的研究。 为了促进这些机制的研究，一系列的自由基时钟将被开发。 这些时钟将用于测量过氧自由基与各种生物相关底物的反应速率。 该技术将允许在宽范围的速率常数的测量。 取代吡啶醇的化学，一类新的抗氧化剂，似乎与过氧自由基的反应比维生素E快10至100倍，将被检查。 各种各样的这些吡啶醇类将被评估为低密度脂蛋白（LDL）中的抗氧化剂，LDL的过氧化作用与冠状动脉疾病的发展有关。 这项研究，这将涉及学生在一个广泛的跨学科计划，预计将提供基础数据，将有助于我们的抗氧化剂化学和生物学的基本理解。