Peroxide Reaction Mechanisms

在有机和大分子化学项目的支持下，范德比尔特大学化学系的Ned Porter教授正在研究有机化合物过氧化反应的机理和有机过氧化物的化学性质。过氧化物分析的新方法（银配位离子喷雾质谱联用高效液相色谱法），加上并行计算分析，导致了对二氧环烷的研究，从过氧化物酸及其共轭碱中能量可达。将制备一类新的化合物吡（mi）二醇，并对其抗氧化性能进行研究。作为自由基引发剂的新偶氮化合物将允许对这些化合物在人体低密度脂质体中作为抗氧化剂进行评估。理论和实验将共同用于开发将脂溶性过氧自由基转化为水溶性超氧自由基的化合物，从而作为自由基链从有机亲脂聚集体“出口”到水的代理。许多有机化合物与分子氧反应生成过氧化产物，这一过程既具有商业重要性，又与人类健康有关。范德比尔特大学化学系的内德·波特（Ned Porter）教授得到了有机和大分子化学计划的支持，他研究了这一过程的化学机制，即自氧化或过氧化反应，以及过氧化化合物的化学反应。他的研究还涉及抑制自氧化和研究新的抗氧化剂。通过计算和实验研究的结合，波特教授正在开发具有潜在活性的新化合物，作为抗氧化剂和将氧化活性从细胞膜转移到水中的媒介，氧化活性会在细胞膜上造成细胞损伤，而在细胞膜上，氧化活性可以在不造成损伤的情况下排出。

With the support of the Organic and Macromolecular Chemistry Program, Professor Ned Porter, of the Department of Chemistry at Vanderbilt University, is studying the mechanism of peroxidation reactions of organic compounds and the chemistry of organic peroxides. New methods for the analysis of peroxides (silver coordination ion spray mass spectrometry coupled to HPLC), coupled with parallel computational analyses, have led to the investigation of dioxiranes, energetically accessible from peroxy acids and their conjugate bases. A new class of compounds, pyri(mi)dinols, will be prepared and studied for their antioxidant properties. New azo compounds that serve as radical initiators will permit the evaluation of these compounds as antioxidants in human low density liposomes. Theory and experiment will together be used to target the development of compounds which will convert a lipid soluble peroxyl radical into a water soluble superoxide radical, thereby acting as agents for the "export" of a free radical chain from an organic lipophilic aggregate into water.Many organic compounds react with molecular oxygen to give peroxide products, a process that has both commercial importance and relevance to human health. Professor Ned Porter, of the Department of Chemistry at Vanderbilt University, is supported by the Organic and Macromolecular Chemistry Program for his study of the mechanism of the chemistry of this process, called autoxidation or peroxidation, and the chemistry of peroxide compounds. His studies also address the inhibition of autoxidation and the study of new antioxidants. Through a combination of calculational and experimental studies, Professor Porter is developing new compounds of potential activity as antioxidants and as agents for the transferral of oxidant activity from the cell membrane, where it causes cellular damage, to water, where the activity may be discharged without causing damage.