Peroxide Reaction Mechanisms

过氧化物反应机理

• 批准号: 0717067
• 负责人: Ned Porter
• 金额: $ 54.9万
• 依托单位: Vanderbilt University
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-09-01 至 2011-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0717067&HistoricalAwards=false
• 关键词: Peroxide; Reaction; Mechanisms

With this award, the Organic and Macromolecular Chemistry Program supports the work of Professor Ned A. Porter of Vanderbilt University. This research will involve investigation of how fats and oils, particularly the polyunsaturated fatty acids, the so-called omega-6 and omega-3 fatty acids, undergo a reaction with molecular oxygen known as lipid peroxidation. The research is intended to provide an understanding of this important chemical reaction at the fundamental level. Among the questions that the research addresses are the following: What are the products of reaction? What biological activities do these products exhibit? (some of the products are known to be pro-inflammatory, others anti-inflammatory) What is the reactivity of different lipids towards this reaction? How can antioxidants stop these harmful reactions? In terms of the broader impacts, this research is quite important since there is evidence implicating increased dietary intake of the omega-3 polyunsaturated fatty esters present in fish oil in the prevention and treatment of a number of diseases in which environmental and lifestyle factors play a role. These include atherosclerotic cardiovascular disease, neurodegenerative disorders, diabetes and cancer, among others. Understanding the chemistry involved could lead to ways to prevent these diseases. In addition, the research will involve students in a broadly interdisciplinary program, with studies on fundamental mechanistic chemistry problems relevant to biological problems. The research will involve women and minority students and there is a student volunteer science outreach programs at Vanderbilt that some of the students will be involved with. There will also be collaborative studies with investigators at the Vanderbilt University Medical School.

有了这个奖项，有机和高分子化学计划支持教授内德A。范德比尔特大学的波特。 这项研究将涉及调查脂肪和油，特别是多不饱和脂肪酸，即所谓的omega-6和omega-3脂肪酸，如何与分子氧发生称为脂质过氧化反应。 这项研究旨在从基础层面上了解这一重要的化学反应。 研究所要解决的问题包括：反应的产物是什么？这些产品表现出哪些生物活性？(some的产品是已知的促炎，其他抗炎）什么是不同的脂质对这个反应的反应？ 抗氧化剂如何阻止这些有害反应？ 就更广泛的影响而言，这项研究非常重要，因为有证据表明，增加鱼油中欧米茄-3多不饱和脂肪酸酯的饮食摄入量，可以预防和治疗环境和生活方式因素发挥作用的许多疾病。 这些疾病包括动脉粥样硬化性心血管疾病、神经退行性疾病、糖尿病和癌症等。 了解所涉及的化学物质可能会导致预防这些疾病的方法。此外，该研究将涉及学生在一个广泛的跨学科计划，与相关的生物问题的基本机械化学问题的研究。 这项研究将涉及妇女和少数民族学生，在范德比尔特有一个学生志愿者科学推广计划，一些学生将参与其中。 还将与范德比尔特大学医学院的研究人员进行合作研究。