New Approaches for Selectivity and Atom Efficiency in the Synthesis of Organic Compounds

本研究的重点是过渡金属配合物催化的合成潜力。涉及Pd、Mo、Ni和W的烯丙基体系将被操纵以获得化学、区域、非映对和对映选择性转化。该项目研究的其他课题包括：分子内碳金属化，金属催化质子转移导致反应中间体可以进行原生环异构化，包括有机硫中间体在内的双功能试剂，以及复合官能团的设计。发展化学反应以减少化学废物的主题贯穿于工作的各个方面。有了这个基于成就的更新奖，合成有机项目正在支持斯坦福大学化学系的巴里·m·特罗斯特博士的研究。特罗斯特教授将专注于开发具有理论和生物学意义的复杂有机分子的高效合成方法，同时提高“原子经济性”。在工作中强调了过渡金属配合物催化量的使用。

The focus of this research is the synthetic potential inherent in catalysis by transition metal complexes. Allyl systems involving Pd, Mo, Ni and W will be manipulated to obtain chemo-, regio-, diastereo-, and enantioselective transformations. Among the other topics to be investigated in the project are: Intramolecular carbametallation, metal catalyzed proton shifts leading to reactive intermediates that can undergo prototropic cycloisomerization, bifunctional reagents including organosulfur intermediates, and the design of composite functional groups. The theme of developing reactions that minimize chemical waste pervades every aspect ofthe work. %%% With this Accomplishment Based Renewal award, the Synthetic Organic Program is supporting the research of Dr. Barry M. Trost of the Department of Chemistry at Stanford University. Professor Trost will focus his work on developing efficient synthetic approaches to complex organic molecules of theoretical and biological interest while increasing "atom economy". The use of catalytic amounts of transition metal complexes is stressed in the work.