New Approaches for Efficiency in Synthetic Organic Chemistry

在这个由化学系化学合成计划资助的项目中，斯坦福大学化学系的巴里·M·特罗斯特教授旨在通过开发不对称催化来提高有机合成的效率。具体地说，催化的三个领域是有针对性的。第一个是合理设计用于形成双核和异核金属络合物的配体作为加成反应的催化剂。第二个领域涉及不对称的三亚甲基甲烷环加成反应。第三部分考察了钯催化的不对称烯丙基和苄基烷基化反应。还将寻求用于不对称合成的新的Ru-Pd顺序反应，并在Mo催化反应的背景下检查这种体系。从生物学到材料科学的各种应用对日益复杂的有机分子的需求加剧了对提高有机合成效率的需求。该项目旨在通过高反应选择性和高原子经济性来实现高合成效率。该项目的成功完成将对制药、农用化学品和特种化学品行业产生积极影响，并为社会的可持续发展做出积极贡献。该项目还将为参与其中的研究生和博士后研究员提供出色的培训，包括那些目前在化学领域任职人数不足的人。

In this project funded by the Chemical Synthesis Program of the Chemistry Division, Professor Barry M. Trost of the Department of Chemistry at Stanford University aims to improve efficiency in organic synthesis through the development of asymmetric catalysis. Specifically, three areas of catalysis are targeted. The first involves the rational design of ligands for formation of dinuclear and heterodinuclear metal complexes as catalysts for addition reactions. The second area involves asymmetric trimethylenemethane cycloadditions. The third area examines Pd catalyzed asymmetric allylic and benzylic alkylation. Novel Ru-Pd sequential reactions for asymmetric synthesis and examination of such systems in the context of Mo catalyzed reactions will also be pursued. The need of increasingly complex organic molecules for a myriad of applications ranging from biology to material science heightens the need for increased efficiency in organic synthesis. This project intends to achieve high synthetic efficiency through high reaction selectivity and high atom economy. Successful accomplishment of this project will positively impact the pharmaceutical, agrochemical and specialty chemical industries and contribute positively to the sustainability of the society. The project will also provide excellent trainings to the graduate students and postdoctoral fellows involved, including those currently underrepresented in Chemistry.