New Approaches for Efficiency in Synthetic Organic Chemistry

提高有机合成化学效率的新方法

• 批准号: 1145236
• 负责人: Barry Trost
• 金额: $ 87万
• 依托单位: Stanford University
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-05-01 至 2015-04-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1145236&HistoricalAwards=false
• 关键词: New; Approaches; Efficiency; Synthetic; Organic

In this project funded by the Chemical Synthesis Program of the Chemistry Division, Professor Barry M. Trost of the Department of Chemistry at Stanford University aims to improve efficiency in organic synthesis through the development of asymmetric catalysis. Specifically, three areas of catalysis are targeted. The first involves the rational design of ligands for formation of dinuclear and heterodinuclear metal complexes as catalysts for addition reactions. The second area involves asymmetric trimethylenemethane cycloadditions. The third area examines Pd catalyzed asymmetric allylic and benzylic alkylation. Novel Ru-Pd sequential reactions for asymmetric synthesis and examination of such systems in the context of Mo catalyzed reactions will also be pursued. The need of increasingly complex organic molecules for a myriad of applications ranging from biology to material science heightens the need for increased efficiency in organic synthesis. This project intends to achieve high synthetic efficiency through high reaction selectivity and high atom economy. Successful accomplishment of this project will positively impact the pharmaceutical, agrochemical and specialty chemical industries and contribute positively to the sustainability of the society. The project will also provide excellent trainings to the graduate students and postdoctoral fellows involved, including those currently underrepresented in Chemistry.

在化学系化学合成项目资助的这一项目中，巴里M.斯坦福大学化学系的特罗斯特旨在通过发展不对称催化来提高有机合成的效率。 具体而言，有三个催化领域的目标。 第一个是合理设计配体，以形成双核和异双核金属配合物作为加成反应的催化剂。 第二个领域涉及不对称三甲基甲烷环加成反应。第三个领域研究钯催化的不对称烯丙基和苄基烷基化。 新颖的钌钯顺序反应的不对称合成和检查这样的系统中的背景下，钼催化的反应也将被追求。 从生物学到材料科学的无数应用对日益复杂的有机分子的需求提高了对有机合成效率的需求。 本项目旨在通过高反应选择性和高原子经济性来实现高合成效率。 该项目的成功完成将对制药、农业化学和特种化学工业产生积极影响，并为社会的可持续发展做出积极贡献。 该项目还将为参与的研究生和博士后研究员提供出色的培训，包括目前在化学领域代表性不足的研究生和博士后研究员。