New Approaches for Efficiency in Synthetic Organic Chemistry
提高有机合成化学效率的新方法
基本信息
- 批准号:0455354
- 负责人:
- 金额:$ 91万
- 依托单位:
- 依托单位国家:美国
- 项目类别:Continuing Grant
- 财政年份:2006
- 资助国家:美国
- 起止时间:2006-01-01 至 2008-12-31
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
With the support of the Organic and Macromolecular Chemistry Program, Professor Barry M. Trost, of the Department of Chemistry at Stanford University, is developing new and efficient approaches for the synthesis of complex organic molecules. Chiral ligands spontaneously promoting the formation of dinuclear metal complexes are being developed for asymmetric catalysis of addition reactions. Guided by mechanistic principles, a novel synthetic method effecting trans hydrometalation is being explored. A variety of metal-mediated methodologies, exploiting the chemistry of ruthenium, rhodium, molybdenum, and vanadium, will be developed, facilitating the construction of complex organic molecules from a range of substrates. Finally, recognizing that not all catalytic events require transition metals, cyclization strategies based on nucleophilic catalysis are opening new doors for unprecedented approaches for organocatalytic polypeptide synthesis.As our knowledge of the structure and reactivity of molecules increases, the practice of organic synthesis is undergoing a change in focus, with the question now more often asked being not if a complex target can be synthesized, but rather how. Practical syntheses derive from the existence of a basic set of synthetic reactions, and the limitations of that base set define the extent to which organic syntheses may be made economical, efficient, and environmentally conscious. With the support of the Organic and Macromolecular Chemistry Program, Professor Barry M. Trost, of the Department of Chemistry at Stanford University, is developing new and selective reactions that add to our arsenal of techniques for the synthesis of the complex organic molecules increasingly forming the basis of a myriad of applications, ranging from biology to materials science.
在有机和高分子化学项目的支持下,巴里M.斯坦福大学化学系的特罗斯特正在开发合成复杂有机分子的新的有效方法。自发促进双核金属配合物形成的手性配体正被开发用于不对称加成反应的催化。以机理原理为指导,探索了一种实现反式金属氢化的新合成方法。各种金属介导的方法,利用钌,铑,钼和钒的化学,将被开发,促进复杂的有机分子从一系列基板的建设。最后,认识到并非所有的催化事件都需要过渡金属,基于亲核催化的环化策略为有机催化多肽合成的前所未有的方法打开了新的大门。随着我们对分子结构和反应性的了解的增加,有机合成的实践正在经历焦点的变化,现在更经常被问到的问题不是是否可以合成复杂的目标,而是怎么做实际的合成源于一组基本的合成反应的存在,并且该基本组的限制限定了有机合成可以经济、有效和环保的程度。在有机和高分子化学项目的支持下,巴里M.斯坦福大学化学系的特罗斯特正在开发新的选择性反应,这些反应增加了我们合成复杂有机分子的技术库,这些复杂有机分子日益成为从生物学到材料科学的无数应用的基础。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Barry Trost其他文献
Barry Trost的其他文献
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{{ truncateString('Barry Trost', 18)}}的其他基金
New Catalytic Reactions for Enhanced Synthetic Efficiency
提高合成效率的新催化反应
- 批准号:
1360634 - 财政年份:2014
- 资助金额:
$ 91万 - 项目类别:
Continuing Grant
New Approaches for Efficiency in Synthetic Organic Chemistry
提高有机合成化学效率的新方法
- 批准号:
1145236 - 财政年份:2012
- 资助金额:
$ 91万 - 项目类别:
Continuing Grant
New Catalytic Reactions for Enhanced Synthetic Efficiency
提高合成效率的新催化反应
- 批准号:
0948222 - 财政年份:2010
- 资助金额:
$ 91万 - 项目类别:
Continuing Grant
New Approaches for Efficiency in Synthetic Organic Chemistry
提高有机合成化学效率的新方法
- 批准号:
0846427 - 财政年份:2009
- 资助金额:
$ 91万 - 项目类别:
Continuing Grant
New Catalytic Reactions for Enhanced Synthetic Efficiency
提高合成效率的新催化反应
- 批准号:
0647358 - 财政年份:2007
- 资助金额:
$ 91万 - 项目类别:
Continuing Grant
New Approaches for Efficiency in Synthetic Organic Chemistry
提高有机合成化学效率的新方法
- 批准号:
0078335 - 财政年份:2001
- 资助金额:
$ 91万 - 项目类别:
Continuing Grant
William S. Johnson Memorial Symposium
威廉·S·约翰逊纪念研讨会
- 批准号:
9634603 - 财政年份:1996
- 资助金额:
$ 91万 - 项目类别:
Standard Grant
New Approaches for Efficiency in the Synthesis of Organic Compounds
提高有机化合物合成效率的新方法
- 批准号:
9501472 - 财政年份:1996
- 资助金额:
$ 91万 - 项目类别:
Continuing Grant
Bilateral United States/Former Soviet Union Workshop on Organic Synthesis
美国/前苏联有机合成双边研讨会
- 批准号:
9401884 - 财政年份:1994
- 资助金额:
$ 91万 - 项目类别:
Standard Grant
New Approaches for Selectivity and Atom Efficiency in the Synthesis of Organic Compounds
有机化合物合成中选择性和原子效率的新方法
- 批准号:
9122761 - 财政年份:1993
- 资助金额:
$ 91万 - 项目类别:
Continuing Grant
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