New Approaches for Efficiency in Synthetic Organic Chemistry

在有机化学和高分子化学项目的支持下，斯坦福大学化学系的巴里·M·特罗斯特教授正在开发合成复杂有机分子的新的有效方法。手性配体自发促进双核金属络合物的形成，用于不对称催化加成反应。在力学原理的指导下，人们正在探索一种新的影响反式氢金属化合成的方法。将开发各种金属介导的方法，利用Ru、Rh、Mo和V的化学，促进从一系列底物构建复杂的有机分子。最后，认识到并不是所有的催化事件都需要过渡金属，基于亲核催化的环化策略正在为有机催化多肽合成开辟了前所未有的新途径。随着我们对分子结构和反应活性的了解的增加，有机合成的实践正在经历着焦点的变化，现在更多的问题不是是否可以合成复杂的目标，而是如何合成。实际的合成源于一组基本的合成反应的存在，而该基础组的局限性决定了有机合成可以在多大程度上实现经济、高效和环保。在有机化学和高分子化学项目的支持下，斯坦福大学化学系的巴里·M·特罗斯特教授正在开发新的选择性反应，这些反应增加了我们合成复杂有机分子的技术，这些技术日益成为从生物学到材料科学的众多应用的基础。

With the support of the Organic and Macromolecular Chemistry Program, Professor Barry M. Trost, of the Department of Chemistry at Stanford University, is developing new and efficient approaches for the synthesis of complex organic molecules. Chiral ligands spontaneously promoting the formation of dinuclear metal complexes are being developed for asymmetric catalysis of addition reactions. Guided by mechanistic principles, a novel synthetic method effecting trans hydrometalation is being explored. A variety of metal-mediated methodologies, exploiting the chemistry of ruthenium, rhodium, molybdenum, and vanadium, will be developed, facilitating the construction of complex organic molecules from a range of substrates. Finally, recognizing that not all catalytic events require transition metals, cyclization strategies based on nucleophilic catalysis are opening new doors for unprecedented approaches for organocatalytic polypeptide synthesis.As our knowledge of the structure and reactivity of molecules increases, the practice of organic synthesis is undergoing a change in focus, with the question now more often asked being not if a complex target can be synthesized, but rather how. Practical syntheses derive from the existence of a basic set of synthetic reactions, and the limitations of that base set define the extent to which organic syntheses may be made economical, efficient, and environmentally conscious. With the support of the Organic and Macromolecular Chemistry Program, Professor Barry M. Trost, of the Department of Chemistry at Stanford University, is developing new and selective reactions that add to our arsenal of techniques for the synthesis of the complex organic molecules increasingly forming the basis of a myriad of applications, ranging from biology to materials science.