New Catalytic Reactions for Enhanced Synthetic Efficiency

该项目围绕着通过使用炔烃作为关键构件来提高合成效率。最值得注意的是，将寻求提高炔烃的化学选择性以及将其化学选择性转化为活性官能团的能力，这将最大限度地减少保护基团的使用，保护基团是导致合成效率低下的主要因素。此外，它还探索了加成反应的发明，在这些反应中，只需要催化，最明显的是基于Ru催化的反应。以前未知或相当困难的转变不仅可能变得可行，而且可能以很高的原子经济性进行。还将研究一种罕见的原理，即使用两个单独的过渡金属催化的反应，在彼此存在的情况下同时或连续发生。此外，还将研究化学、区域、非对映和对映体选择性反应中Ru烯醇酸盐的形成和反应活性。通过这一奖项，化学合成计划正在支持斯坦福大学化学系的Barry M.Trost教授的研究。特罗斯特教授的计划将有助于通过设计使复杂生物活性分子的合成更加环保。通过这样做，它将有助于将化学工业中环境最差的部门之一--特种化学工业--包括制药和农化工业--转变为一个更环保的部门。

This project revolves around the enhancement in synthetic efficiency by using alkynes as key building blocks. Most notably, the enhanced chemoselectivity of an alkyne as well as its ability to be chemoselectively transformed into reactive functional groups will be pursued, which should minimize the use of protecting groups, a major contributor to synthetic inefficiency. Furthermore, it explores the invention of addition reactions where anything else is needed only catalytically, most notably reactions based on ruthenium catalysis. Transformations that previously were unknown or quite difficult not only may become feasible but may be performed with high atom economy. A rare principle, the use of two separate transition metal catalyzed reactions occurring in the presence of each other either concurrently or consecutively, will also be examined. In addition, the formation and reactivity of ruthenium enolates will be studied for chemo, regio-, diastereo-, and enantioselective reactions. With this award, the Chemical Synthesis Program is supporting the research of Professor Barry M. Trost of the Department of Chemistry at Stanford University. Professor Trost's program will contribute to making the synthesis of complex bioactive molecules more environmentally benign by design. By so doing, it will help transform one of the most environmentally poor sectors of the chemical industry, the specialty chemical industry which includes both the pharmaceutical and agrichemical industries, into a much more environmentally sound one.