New Catalytic Reactions for Enhanced Synthetic Efficiency

提高合成效率的新催化反应

• 批准号: 0948222
• 负责人: Barry Trost
• 金额: $ 46.5万
• 依托单位: Stanford University
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-05-01 至 2013-04-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0948222&HistoricalAwards=false
• 关键词: New; Catalytic; Reactions; Enhanced; Synthetic

This project revolves around the enhancement in synthetic efficiency by using alkynes as key building blocks. Most notably, the enhanced chemoselectivity of an alkyne as well as its ability to be chemoselectively transformed into reactive functional groups will be pursued, which should minimize the use of protecting groups, a major contributor to synthetic inefficiency. Furthermore, it explores the invention of addition reactions where anything else is needed only catalytically, most notably reactions based on ruthenium catalysis. Transformations that previously were unknown or quite difficult not only may become feasible but may be performed with high atom economy. A rare principle, the use of two separate transition metal catalyzed reactions occurring in the presence of each other either concurrently or consecutively, will also be examined. In addition, the formation and reactivity of ruthenium enolates will be studied for chemo, regio-, diastereo-, and enantioselective reactions. With this award, the Chemical Synthesis Program is supporting the research of Professor Barry M. Trost of the Department of Chemistry at Stanford University. Professor Trost's program will contribute to making the synthesis of complex bioactive molecules more environmentally benign by design. By so doing, it will help transform one of the most environmentally poor sectors of the chemical industry, the specialty chemical industry which includes both the pharmaceutical and agrichemical industries, into a much more environmentally sound one.

该项目围绕使用炔作为关键构件来提高合成效率。 最值得注意的是，将追求炔的增强的化学选择性以及其被化学选择性地转化为反应性官能团的能力，这将使保护基团的使用最小化，保护基团是合成效率低下的主要原因。 此外，它还探索了加成反应的发明，其中只需要催化剂，最值得注意的是基于钌催化的反应。以前未知或相当困难的转换不仅可能变得可行，而且可以以高原子经济性进行。 一个罕见的原则，使用两个单独的过渡金属催化的反应发生在对方同时或连续的存在下，也将被检查。 此外，钌烯醇化物的形成和反应性将被研究的化学，区域，非对映体，和对映体选择性反应。 有了这个奖项，化学合成计划是支持教授巴里M。斯坦福大学化学系的特罗斯特说。 Trost教授的项目将有助于通过设计使复杂生物活性分子的合成更加环保。 通过这样做，它将有助于将化学工业中环境最差的部门之一-包括制药和农用化学工业在内的特种化学工业-转变为一个更加无害环境的部门。